TRRUST (version1) is

a manually curated database of human transcriptional regulatory network.

Notice: TRRUST version 2 is now available from HERE.

TRRUST (v1) contains 8,015 transcriptional regulatory relationships between 748 human transcription factors (TFs) and 1,975 non-TF genes, derived from 6,175 pubmed articles, which describe small-scale experimental studies of transcriptional regulations. To efficiently search for regulatory relationships from over 20 million pubmed articles, we used sentence-based text mining approach.

TRRUST database also provide information of mode of regulation (activation or repression). Currently 4,861 (60.6%) regulatory relationships are known for mode of regulation.

Tables for 748 human TFs and 1,975 non-TF genes included in TRRUST.

TRRUST network edge information is freely available for non-commercial research at Download page.


2014.06.24 TRRUST website launched

How to cite TRRUST

TRRUST: A reference database of human transcriptional regulatory interactions. Scientific Reports 5:11432 12 Jun, 2015 (link)

Contact information

Insuk Lee (Email : insuklee (at)


This work was supported by the National Research Foundation of Korea grant (2010-0017649, 2012M3A9B4028641, 2012M3A9C7050151).