TRRUST (version 2) is

a manually curated database of human and mouse transcriptional regulatory networks.

Current version of TRRUST contains 8,444 and 6,552 TF-target regulatory relationships of 800 human TFs and 828 mouse TFs, respectively. They have been derived from 11,237 pubmed articles, which describe small-scale experimental studies of transcriptional regulations. To efficiently search for regulatory relationships from over 20 million pubmed articles, we used sentence-based text mining approach.

TRRUST database also provides information of mode of regulation (activation or repression). Currently 8,972 (59.8%) regulatory relationships are known for mode of regulation.

Tables for human genes and mouse genes included in TRRUST.

TRRUST network edge information is freely available for non-commercial research at Download page.

* TRRUST version 1 website can be found HERE.


2014.06.24 TRRUST website launched
2017.05.25 Human TRRUST data has been updated
2017.05.25 Mouse TRRUST data has been added

How to cite TRRUST

TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions. Nucleic Acids Research 26 Oct, 2017 (link)

Contact information

Insuk Lee (Email : insuklee (at)


This work was supported by the National Research Foundation of Korea grant (2017M3A9B4042581, 2015R1A2A1A15055859).