TP53 is a Transcription Factor.

1. Targets and Regulators

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TP53 targets

#	TF	Target	Mode of Regulation	References (PMID)
1	TP53	ABCB1	Repression	10029407
2	TP53	ABCB1	Unknown	18234965
3	TP53	AFP	Repression	14522900
4	TP53	AKT1	Repression	12485897
5	TP53	ALKBH2	Unknown	20661249
6	TP53	ALOX5	Unknown	17018618
7	TP53	ANKRD1	Unknown	20599664
8	TP53	ANTXR1	Unknown	11711532
9	TP53	APAF1	Unknown	11896574; 15972851
10	TP53	APCS	Activation	15378026
11	TP53	AQP3	Unknown	11231003
12	TP53	ATF3	Activation	12372430
13	TP53	ADGRB1	Unknown	11875720
14	TP53	BAX	Activation	10101800; 10566557; 15851483; 17280505; 17693666; 18172861; 20673369; 22532570; 22732402; 9000137
15	TP53	BAX	Unknown	10559267; 11278953; 12851404; 15988033; 19067706; 21859835
16	TP53	BBC3	Activation	17280505
17	TP53	BBC3	Unknown	11572983; 15988033; 18755897; 22763818
18	TP53	BCL2	Repression	11313951; 17693666; 19411072; 20428827; 9000137
19	TP53	BCL2	Unknown	21859835
20	TP53	BCL2L1	Activation	9000137
21	TP53	BCL2L1	Repression	18172861
22	TP53	BCL3	Repression	12808109
23	TP53	BDKRB2	Activation	15632413
24	TP53	BGLAP	Activation	21964930
25	TP53	BIRC5	Repression	17124180
26	TP53	BIRC5	Unknown	19067706
27	TP53	BRCA1	Repression	9619832
28	TP53	BRCA1	Unknown	21742769
29	TP53	BRCA2	Repression	18765668; 9619832
30	TP53	BTG2	Unknown	16581545
31	TP53	BTG3	Unknown	18590053
32	TP53	BTS1	Unknown	9030974
33	TP53	CABLES1	Unknown	11706030
34	TP53	CARM1	Unknown	20462455
35	TP53	CASP1	Unknown	11278253
36	TP53	CASP3	Unknown	21859835
37	TP53	CAV1	Activation	10684646
38	TP53	CCNA1	Unknown	17530187
39	TP53	CCNA2	Unknown	8270002
40	TP53	CCNB1	Repression	11892838
41	TP53	CCNB2	Repression	12889596
42	TP53	CCND1	Repression	12808109
43	TP53	CD82	Activation	9736732
44	TP53	CDK1	Repression	12889596
45	TP53	CDK1	Unknown	19067706
46	TP53	CDK2	Repression	12732645
47	TP53	CDK4	Unknown	17530187
48	TP53	CDKN1A	Activation	10101800; 10327058; 10499591; 10522058; 10566557; 10597242; 11444825; 11892838; 12665570; 12889596; 12902982; 14522900; 15851483; 15882981; 15897882; 17280505; 18172861; 18645021; 19501055; 19713748; 20673369; 21084835; 21245169; 21557991; 22532570; 22732402; 7753560; 9916993
49	TP53	CDKN1A	Repression	15208672; 16970927; 17344317
50	TP53	CDKN1A	Unknown	10559267; 10910098; 12007564; 12420214; 12851404; 15509808; 15539944; 15856024; 15988033; 16103882; 16434701; 16540664; 16557594; 16581545; 17996705; 18225552; 18755897; 19067706; 19954840; 20036872; 20190809; 20531308; 21858218; 21900401
51	TP53	CDKN1B	Unknown	15988033
52	TP53	CHEK1	Repression	15016801
53	TP53	CHEK1	Unknown	11152453
54	TP53	CHEK2	Repression	10531348
55	TP53	CHUK	Repression	15469934
56	TP53	CKM	Activation	8389468
57	TP53	CRYAB	Activation	21556774
58	TP53	CTNNB1	Repression	19411072
59	TP53	CTSD	Activation	10029407
60	TP53	CYFIP2	Unknown	15856024
61	TP53	DDB1	Activation	16357511
62	TP53	DDB1	Repression	19382146
63	TP53	DDB2	Activation	16357511
64	TP53	DDB2	Unknown	12771027; 12967652; 15856024; 15927209; 22336944
65	TP53	DKK1	Unknown	15229249
66	TP53	DNMT1	Activation	20570896
67	TP53	DNMT1	Repression	20570896; 21478913
68	TP53	DNMT1	Unknown	18555750
69	TP53	DUSP1	Activation	12890671; 15611668
70	TP53	E2F1	Repression	8557038
71	TP53	E2F3	Repression	20428827
72	TP53	E2F7	Activation	22802528
73	TP53	EGFR	Activation	10029407
74	TP53	EGR1	Unknown	16990849
75	TP53	ELF4	Unknown	20805247
76	TP53	EPHA2	Activation	11641774
77	TP53	ESR1	Unknown	21655924
78	TP53	EZH2	Activation	15208672
79	TP53	EZH2	Repression	15208672; 21165554
80	TP53	FAS	Activation	10101800; 11313989
81	TP53	FAS	Unknown	16317104
82	TP53	FDXR	Unknown	12370809
83	TP53	FGF2	Repression	10029407
84	TP53	FLT1	Activation	16432214
85	TP53	FLT1	Unknown	1724219e
86	TP53	FOXM1	Repression	21518729
87	TP53	FOXO3	Unknown	19299143
88	TP53	FRMD5	Unknown	19139068
89	TP53	FUS	Unknown	12364590
90	TP53	GADD45A	Activation	10566557
91	TP53	GADD45A	Repression	17344317; 18350249
92	TP53	GADD45A	Unknown	10327059; 12007564; 15031557; 16581545; 18225552
93	TP53	GC	Unknown	8642300
94	TP53	GDF15	Activation	10618379
95	TP53	GDF15	Unknown	10777512
96	TP53	GLI2	Unknown	18813803
97	TP53	GML	Activation	10717525
98	TP53	GPNMB	Unknown	15684612
99	TP53	GSTP1	Activation	18505928
100	TP53	HIPK2	Activation	11740489
101	TP53	HNF4A	Repression	16895524
102	TP53	HRAS	Unknown	11127813
103	TP53	HSF1	Unknown	20180806
104	TP53	HSP90AB1	Repression	15284248
105	TP53	ID1	Unknown	16557594
106	TP53	ID2	Unknown	16557594
107	TP53	IER3	Unknown	12360408
108	TP53	IFI16	Activation	18974396
109	TP53	IFI16	Unknown	11146555
110	TP53	IGF1R	Repression	12444079; 17097318
111	TP53	IGF1R	Unknown	11001824; 17600529
112	TP53	IGFBP3	Activation	10101800
113	TP53	ING1	Unknown	16465410
114	TP53	IPO7	Repression	22284678
115	TP53	KLF2	Repression	23202365
116	TP53	MAD1L1	Repression	12876282
117	TP53	MAP4	Repression	19411072
118	TP53	MCL1	Repression	19411072
119	TP53	MCM7	Repression	15899946
120	TP53	MDM2	Activation	10566557; 10718212; 12902982; 15851483; 20837136; 22223137; 22532570; 9645455; 9858609
121	TP53	MDM2	Unknown	10469568; 12851404; 14532965; 15856024; 18566224; 18583933; 20036872; 22180176; 9071998
122	TP53	MDM4	Unknown	20036872; 20372076
123	TP53	MET	Repression	21831840
124	TP53	MGMT	Repression	17564708; 19846904
125	TP53	MGMT	Unknown	20525765
126	TP53	MKI67	Unknown	14675138
127	TP53	MMP1	Repression	15108353
128	TP53	MMP2	Activation	10029407; 11792711; 9343394
129	TP53	MMP2	Unknown	19853299; 19939245
130	TP53	MUC2	Activation	12374798
131	TP53	MYC	Repression	19411072
132	TP53	MYC	Unknown	19202062
133	TP53	NFKB1	Unknown	15988033
134	TP53	NKX3-1	Repression	17202838
135	TP53	NLRC4	Activation	15580302
136	TP53	NME1	Unknown	12669312
137	TP53	OGG1	Activation	16293709
138	TP53	PAX5	Activation	21319196
139	TP53	PDGFRB	Activation	18697203
140	TP53	PERP	Repression	17344317
141	TP53	PERP	Unknown	15856024
142	TP53	PIAS3	Repression	11877452
143	TP53	PLAGL1	Unknown	11896574
144	TP53	PLK1	Unknown	24076372
145	TP53	PLK3	Unknown	16581545
146	TP53	PMAIP1	Activation	14695212
147	TP53	PMAIP1	Unknown	15856024
148	TP53	PML	Activation	14992722
149	TP53	POLD1	Unknown	11375983
150	TP53	PPARGC1A	Unknown	19139068
151	TP53	PTPA	Repression	10787423
152	TP53	PRC1	Repression	12889596
153	TP53	PRG3	Unknown	12135761
154	TP53	PRKAB1	Unknown	12771025
155	TP53	PTEN	Repression	17344317
156	TP53	PTEN	Unknown	11545734
157	TP53	PTPN13	Unknown	11696979
158	TP53	PTTG1	Activation	12355087
159	TP53	PTTG1	Repression	15016801
160	TP53	RAD51B	Unknown	9878257
161	TP53	RASSF1	Repression	21364923
162	TP53	RB1	Unknown	8119988
163	TP53	RECQL4	Activation	15674334
164	TP53	REEP5	Repression	8557038
165	TP53	RELA	Unknown	15988033
166	TP53	RRM2B	Unknown	10716435; 15856024
167	TP53	S100B	Activation	15178678
168	TP53	SFN	Activation	10101800
169	TP53	SIAH1	Unknown	20421190
170	TP53	SIVA1	Activation	15105421
171	TP53	SIVA1	Activation	15105421
172	TP53	SLC2A1	Repression	22483234
173	TP53	SLC6A6	Repression	16734743
174	TP53	SMAD3	Unknown	21900401
175	TP53	SSTR2	Repression	14695784
176	TP53	STAT1	Unknown	12364590
177	TP53	STAT3	Repression	11809683
178	TP53	TBXAS1	Repression	14586398
179	TP53	TCEAL1	Unknown	20421190
180	TP53	TCF7L2	Repression	14990988
181	TP53	TERT	Repression	10778946; 18754863
182	TP53	THBS1	Activation	10029407; 10101800
183	TP53	THBS1	Unknown	19826414
184	TP53	TNFRSF10A	Activation	11313989
185	TP53	TNFRSF10B	Activation	10101800; 11313989; 11756185
186	TP53	TNFRSF10B	Unknown	10810622; 19351839
187	TP53	TP53	Activation	22532570
188	TP53	TP53	Unknown	11032029; 16990849
189	TP53	TP53I3	Activation	10101800; 14695213
190	TP53	TP53I3	Unknown	12851404
191	TP53	TP73	Unknown	11238924; 16990849
192	TP53	TRIM22	Activation	15064739
193	TP53	TYMS	Repression	21351099
194	TP53	UHRF1	Repression	18220474; 19501055
195	TP53	UHRF1BP1	Activation	18220474
196	TP53	VCAN	Activation	12438652
197	TP53	VEGFA	Activation	16684540
198	TP53	VEGFA	Repression	11559575
199	TP53	WRN	Repression	11427532
200	TP53	XPC	Unknown	12771027; 12967652; 15927209; 16357511; 22336944
201	TP53	XPO1	Repression	22284678

Modularity measured by P value : 0.001

TFs that regulate TP53

#	TF	Target	Mode of Regulation	References (PMID)
1	AATF	TP53	Unknown	17157788
2	ABL1	TP53	Activation	11753601
3	ATF3	TP53	Unknown	22991139
4	BDP1	TP53	Unknown	12734418
5	CREBBP	TP53	Unknown	15154850
6	DNMT1	TP53	Unknown	24006445
7	E2F1	TP53	Activation	15706352
8	E2F1	TP53	Repression	8557038
9	E2F1	TP53	Unknown	12625370; 21441950; 22241525
10	EGR1	TP53	Activation	9242687
11	ELF4	TP53	Repression	20805247
12	ERCC2	TP53	Activation	22387547
13	ESR1	TP53	Repression	17681750
14	ETS1	TP53	Unknown	10510472
15	ETS2	TP53	Unknown	10510472
16	EZH2	TP53	Repression	20132185
17	EZH2	TP53	Unknown	24006445
18	FOS	TP53	Unknown	10348347
19	HDAC1	TP53	Repression	15130752
20	HDAC9	TP53	Repression	15964798
21	HIPK2	TP53	Unknown	12851404
22	HMGA1	TP53	Unknown	20335021
23	HOXA10	TP53	Activation	21993662
24	IFI16	TP53	Unknown	22618232
25	IKBKB	TP53	Unknown	24006445
26	ING1	TP53	Activation	15662138; 16325212
27	ING4	TP53	Activation	19895734
28	IRF1	TP53	Unknown	19003964
29	JUN	TP53	Repression	22859294
30	JUN	TP53	Unknown	10348347
31	KLF4	TP53	Activation	21132436
32	KLF4	TP53	Repression	17308127
33	KLF4	TP53	Unknown	18511453
34	MDM4	TP53	Unknown	11528400; 17499002; 17875722; 19910468
35	MYC	TP53	Activation	8494784
36	MYC	TP53	Unknown	19086036
37	MYCN	TP53	Activation	19885598; 21862876
38	MYCN	TP53	Repression	21862876
39	NF1	TP53	Activation	10634504; 8816507
40	NFKB1	TP53	Unknown	10348347; 11032029
41	NR3C1	TP53	Repression	17016446
42	NUPR1	TP53	Unknown	22858377
43	PAX2	TP53	Repression	8521821
44	PAX5	TP53	Activation	22105368
45	PAX5	TP53	Repression	8521821
46	PAX8	TP53	Repression	8521821
47	PML	TP53	Unknown	12837275
48	PPARG	TP53	Activation	14960510; 16887883
49	RELA	TP53	Unknown	10348347; 11032029; 15155458
50	RUVBL1	TP53	Repression	21617703
51	SIRT1	TP53	Activation	23661372
52	SIRT1	TP53	Repression	15130752; 15632193
53	SOX6	TP53	Activation	21084391
54	STAT1	TP53	Activation	14602726
55	STAT1	TP53	Unknown	24655378
56	STAT3	TP53	Unknown	20043094
57	TFDP1	TP53	Repression	8557038
58	TP53	TP53	Activation	22532570
59	TP53	TP53	Unknown	11032029; 16990849
60	VHL	TP53	Unknown	22071692
61	YEATS4	TP53	Repression	18214854
62	YY1	TP53	Activation	10634504; 8816507
63	YY1	TP53	Repression	10787423
64	YY1	TP53	Unknown	10505791
65	ZBTB2	TP53	Repression	19380588

Modularity measured by P value : 0.001

2. Other TFs that share targets with TP53

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TFs that share targets with TP53

*P values are calculated with hypergeometric test.

TF	# of overlapped target genes	P value	FDR
E2F1	33	3.91e-38	9.47e-36
SP1	49	4.46e-38	1.05e-35
RELA	41	1.68e-36	3.71e-34
NFKB1	39	8.91e-34	1.62e-31
MYC	24	3.66e-27	4.16e-25
EP300	20	3.36e-26	3.65e-24
ESR1	21	4.86e-26	5.13e-24
ATM	15	9.40e-26	9.63e-24
HDAC1	21	1.20e-25	1.22e-23
STAT3	25	6.92e-25	5.93e-23
TP73	12	1.86e-24	1.52e-22
BRCA1	18	1.85e-23	1.36e-21
SIRT1	16	1.37e-20	8.36e-19
JUN	20	6.38e-18	2.88e-16
AR	16	6.12e-16	2.25e-14
EGR1	15	2.38e-15	7.97e-14
MYCN	12	1.31e-14	3.99e-13
KLF4	11	2.37e-14	6.91e-13
PGR	10	2.42e-14	7.03e-13
PAX5	9	6.83e-14	1.82e-12
ETS1	14	7.79e-14	2.03e-12
RB1	10	8.01e-14	2.07e-12
E2F3	8	1.85e-13	4.57e-12
SOX6	6	4.24e-13	9.80e-12
WT1	11	2.28e-12	4.47e-11
PML	8	3.49e-12	6.60e-11
HIF1A	12	1.26e-11	2.13e-10
ETS2	9	1.48e-11	2.48e-10
PPARG	11	2.06e-11	3.36e-10
ING4	7	2.18e-11	3.50e-10
TP63	7	2.18e-11	3.50e-10
E2F4	8	2.89e-11	4.59e-10
NR3C1	9	3.33e-11	5.17e-10
TBP	7	3.85e-11	5.92e-10
MTA1	8	4.14e-11	6.36e-10
FHL2	5	4.97e-11	7.51e-10
TCF4	8	5.84e-11	8.64e-10
HOXB7	6	8.65e-11	1.22e-09
MECP2	6	1.89e-10	2.49e-09
DNMT1	8	2.01e-10	2.61e-09
YBX1	8	2.01e-10	2.61e-09
CEBPB	10	2.13e-10	2.74e-09
TFAP2A	10	6.17e-10	6.92e-09
IRF1	9	6.77e-10	7.47e-09
AATF	5	1.03e-09	1.08e-08
KAT2B	6	1.20e-09	1.23e-08
ERCC2	5	2.72e-09	2.54e-08
ING1	5	2.72e-09	2.54e-08
BCL6	7	3.65e-09	3.27e-08
PARP1	7	3.65e-09	3.27e-08
PTTG1	6	4.84e-09	4.19e-08
CREBBP	7	6.18e-09	5.21e-08
STAT1	10	9.14e-09	7.31e-08
ABL1	5	1.21e-08	9.42e-08
ATF2	7	1.27e-08	9.84e-08
KLF5	6	1.48e-08	1.12e-07
KLF6	6	1.48e-08	1.12e-07
HIC1	5	2.20e-08	1.58e-07
TWIST1	7	2.42e-08	1.72e-07
ATF3	6	2.82e-08	1.95e-07
HDAC9	6	2.82e-08	1.95e-07
ZNF24	4	2.87e-08	1.99e-07
FOS	8	3.48e-08	2.34e-07
EZH2	7	6.29e-08	3.93e-07
FLI1	6	6.54e-08	4.06e-07
HDAC3	6	8.44e-08	5.05e-07
NR1I2	6	8.44e-08	5.05e-07
RBL1	4	8.56e-08	5.10e-07
NF1	5	9.33e-08	5.46e-07
HDAC2	6	1.36e-07	7.55e-07
NR4A1	5	1.39e-07	7.70e-07
HOXA1	4	1.98e-07	1.05e-06
SMAD3	6	3.18e-07	1.58e-06
CEBPA	7	5.12e-07	2.40e-06
GLI1	5	5.23e-07	2.44e-06
ESR2	5	6.92e-07	3.08e-06
VHL	5	6.92e-07	3.08e-06
ATF4	6	9.27e-07	3.93e-06
SP3	9	9.33e-07	3.95e-06
ARNT	5	1.16e-06	4.75e-06
NFYA	5	1.16e-06	4.75e-06
HIPK2	4	1.17e-06	4.76e-06
NKX3-1	4	1.17e-06	4.76e-06
SMAD7	4	1.17e-06	4.76e-06
TFDP1	4	1.17e-06	4.76e-06
ZNF382	4	1.17e-06	4.76e-06
CTNNB1	5	1.47e-06	5.77e-06
GATA3	6	1.71e-06	6.56e-06
USF1	7	1.81e-06	6.89e-06
DNMT3A	4	1.82e-06	6.91e-06
NPM1	4	1.82e-06	6.91e-06
YY1	8	2.09e-06	7.75e-06
TCF7L2	4	2.71e-06	9.57e-06
APC	4	3.89e-06	1.29e-05
MITF	5	4.14e-06	1.36e-05
RUNX3	5	5.92e-06	1.82e-05
BCL3	3	6.61e-06	1.99e-05
CHD8	3	6.61e-06	1.99e-05
KDM4B	3	6.61e-06	1.99e-05
NUPR1	3	6.61e-06	1.99e-05
TSC22D3	3	6.61e-06	1.99e-05
UHRF1	3	6.61e-06	1.99e-05
ZNF300	3	6.61e-06	1.99e-05
TCF3	4	7.32e-06	2.18e-05
CDX2	5	9.66e-06	2.73e-05
CTCF	5	1.12e-05	3.09e-05
DDIT3	4	1.26e-05	3.39e-05
ARID3A	3	1.31e-05	3.49e-05
GTF3A	3	1.31e-05	3.49e-05
IFI16	3	1.31e-05	3.49e-05
MBD1	3	1.31e-05	3.49e-05
CREB1	7	1.57e-05	4.05e-05
FOXM1	4	1.61e-05	4.12e-05
FOXO3	4	1.61e-05	4.12e-05
LEF1	5	1.72e-05	4.38e-05
NFKBIA	4	2.02e-05	4.97e-05
MSX2	3	2.28e-05	5.49e-05
ATF5	3	3.63e-05	8.02e-05
E2F6	3	3.63e-05	8.02e-05
IRF9	3	3.63e-05	8.02e-05
MYBL2	3	3.63e-05	8.02e-05
STAT5B	3	3.63e-05	8.02e-05
FOXA1	4	3.74e-05	8.22e-05
AHR	4	4.49e-05	9.43e-05
ATF1	4	5.35e-05	1.08e-04
ETV4	4	5.35e-05	1.08e-04
HOXA9	3	5.41e-05	1.09e-04
NANOG	4	6.33e-05	1.24e-04
USF2	5	6.93e-05	1.34e-04
VDR	5	6.93e-05	1.34e-04
FOXO1	4	7.43e-05	1.42e-04
POU5F1	4	7.43e-05	1.42e-04
MBD2	3	7.67e-05	1.46e-04
TFAP2C	3	7.67e-05	1.46e-04
SMAD4	4	8.66e-05	1.61e-04
MSC	3	1.05e-04	1.89e-04
NFATC2	3	1.05e-04	1.89e-04
SRF	4	1.51e-04	2.56e-04
HSF1	4	1.94e-04	3.14e-04
JUND	4	2.18e-04	3.46e-04
NFYC	3	2.27e-04	3.57e-04
STAT5A	3	2.27e-04	3.57e-04
JUNB	3	2.82e-04	4.28e-04
NFYB	3	2.82e-04	4.28e-04
SATB1	3	2.82e-04	4.28e-04
POU2F1	4	3.38e-04	5.00e-04
STAT6	4	4.13e-04	5.89e-04
GLI2	3	4.95e-04	6.86e-04
HMGA1	3	4.95e-04	6.86e-04
ELK1	3	6.83e-04	8.96e-04
NR1H4	3	6.83e-04	8.96e-04
RUNX2	3	6.83e-04	8.96e-04
HNF4A	4	7.07e-04	9.24e-04
ETV6	2	7.56e-04	9.77e-04
HCFC1	2	7.56e-04	9.77e-04
ID2	2	7.56e-04	9.77e-04
PIAS3	2	7.56e-04	9.77e-04
TNFAIP3	2	7.56e-04	9.77e-04
BTG2	2	1.13e-03	1.38e-03
ELF4	2	1.13e-03	1.38e-03
HDGF	2	1.13e-03	1.38e-03
MAX	2	1.13e-03	1.38e-03
MYOD1	2	1.13e-03	1.38e-03
MYOG	2	1.13e-03	1.38e-03
MZF1	2	1.13e-03	1.38e-03
PAX3	2	1.13e-03	1.38e-03
PRDM1	2	1.13e-03	1.38e-03
SMAD2	2	1.13e-03	1.38e-03
WWP1	2	1.13e-03	1.38e-03
WWTR1	2	1.13e-03	1.38e-03
ZBTB16	2	1.13e-03	1.38e-03
HDAC4	3	1.18e-03	1.43e-03
SOX2	3	1.33e-03	1.60e-03
TWIST2	3	1.33e-03	1.60e-03
CREM	3	1.50e-03	1.77e-03
GFI1	2	1.57e-03	1.85e-03
KLF10	2	1.57e-03	1.85e-03
LMO4	2	1.57e-03	1.85e-03
NCOR1	2	1.57e-03	1.85e-03
TFAP4	2	1.57e-03	1.85e-03
RARA	3	1.68e-03	1.96e-03
SREBF1	3	1.68e-03	1.96e-03
APEX1	2	2.08e-03	2.38e-03
CEBPE	2	2.08e-03	2.38e-03
HDAC5	2	2.08e-03	2.38e-03
HES1	2	2.08e-03	2.38e-03
MAZ	2	2.08e-03	2.38e-03
PAX8	2	2.08e-03	2.38e-03
FOSL1	2	2.66e-03	2.97e-03
GATA6	2	2.66e-03	2.97e-03
NCOA3	2	2.66e-03	2.97e-03
SMARCA4	2	2.66e-03	2.97e-03
SP4	2	2.66e-03	2.97e-03
EPAS1	2	3.31e-03	3.62e-03
TAL1	2	3.31e-03	3.62e-03
ZFP36	2	3.31e-03	3.62e-03
MEN1	2	4.02e-03	4.33e-03
NR0B2	2	4.02e-03	4.33e-03
FOXP3	2	4.79e-03	5.11e-03
PAX6	2	4.79e-03	5.11e-03
STAT4	2	4.79e-03	5.11e-03
MYB	3	4.85e-03	5.16e-03
RUNX1	3	5.58e-03	5.91e-03
HDAC7	2	5.63e-03	5.96e-03
STAT2	2	5.63e-03	5.96e-03
FOSL2	2	7.50e-03	7.79e-03
HOXA10	2	7.50e-03	7.79e-03
PITX1	2	8.52e-03	8.81e-03
SREBF2	2	1.32e-02	1.34e-02
XBP1	2	1.32e-02	1.34e-02
SNAI2	2	1.45e-02	1.47e-02
REL	2	1.58e-02	1.61e-02
SOX9	2	2.02e-02	2.04e-02
HNF1A	2	2.50e-02	2.52e-02

3. Diseases / Pathways associated with TP53

top

- Disease Ontology terms

#	Description	Term ID	# of overlapped genes	P value	FDR

1	cancer	DOID:162	77	6.072e-62	1.066e-58
2	Malignant Neoplasms	DOID:462	72	6.153e-56	6.267e-53
3	Embryoma	DOID:4766	61	3.480e-52	2.954e-49
4	Malignant neoplasm of prostate	DOID:10283	56	3.186e-48	2.135e-45
5	Malignant neoplasm of breast	DOID:4241	59	5.514e-46	3.120e-43
6	Carcinoma of the Large Intestine	DOID:1994	45	2.289e-44	1.143e-41
7	Malignant neoplasm of stomach	DOID:10534	38	2.781e-37	8.139e-35
8	Primary carcinoma of the liver cells	DOID:684	40	1.402e-36	3.880e-34
9	Squamous cell carcinoma	DOID:1749	35	8.658e-35	2.120e-32
10	Neoplasm Metastasis	DOID:2619	40	2.622e-34	6.240e-32
11	Melanoma	DOID:1909	37	3.491e-34	8.155e-32
12	Primary Tumor	DOID:8176	25	2.899e-33	6.363e-31
13	disease	DOID:4	85	4.863e-33	1.058e-30
14	Breast Carcinoma	DOID:3459	27	5.793e-31	1.101e-28
15	Carcinoma	DOID:305	29	9.925e-31	1.845e-28
16	Malignant neoplasm of cervix uteri	DOID:4361	25	3.511e-30	6.209e-28
17	Osteosarcoma	DOID:3347	23	7.682e-30	1.270e-27
18	Malignant neoplasm of pancreas	DOID:1793	30	1.350e-29	2.176e-27
19	Renal Cell Carcinoma	DOID:4450	28	3.101e-29	4.850e-27
20	Cervical Squamous Cell Carcinoma	DOID:3744	22	5.851e-28	8.186e-26
21	Malignant neoplasm of lung	DOID:1324	31	1.324e-27	1.765e-25
22	Osteosarcoma of Bone	DOID:3376	21	2.520e-27	3.274e-25
23	Retinoblastoma	DOID:768	17	2.541e-27	3.285e-25
24	Metastasis to Lymph Nodes	DOID:10437	23	6.574e-27	8.166e-25
25	Malignant neoplasm of urinary bladder	DOID:11054	22	4.870e-26	5.487e-24
26	Neuroblastoma	DOID:769	23	1.527e-25	1.641e-23
27	Neoplasm, Ovarian	DOID:2394	19	2.926e-25	3.029e-23
28	Glioblastoma	DOID:3068	22	3.261e-25	3.335e-23
29	Adenocarcinoma	DOID:299	25	2.394e-24	2.266e-22
30	Leukemia	DOID:1240	28	3.599e-24	3.357e-22
31	Malignant tumor of colon	DOID:219	27	8.552e-24	7.641e-22
32	Malignant neoplasm of ovary	DOID:2144	26	8.933e-24	7.953e-22
33	Endometrial Carcinoma	DOID:2871	21	1.115e-22	8.955e-21
34	Stomach Carcinoma	DOID:5517	20	2.713e-22	2.106e-20
35	Adenoma	DOID:657	18	8.522e-21	5.651e-19
36	Prostate carcinoma	DOID:10286	16	7.709e-20	4.576e-18
37	Squamous Cell Carcinoma of Esophagus	DOID:3748	18	1.284e-19	7.381e-18
38	Glioma	DOID:2627	22	2.875e-19	1.609e-17
39	Infection	DOID:945	24	4.632e-19	2.553e-17
40	Multiple Myeloma	DOID:9538	19	6.706e-19	3.641e-17
41	Myeloid leukemia, acute	DOID:9119	21	1.330e-18	7.029e-17
42	Carcinoma, Transitional Cell	DOID:3995	14	1.612e-18	8.430e-17
43	Malignant neoplasm of endometrium	DOID:5654	15	2.569e-18	1.300e-16
44	Malignant Glioma	DOID:3070	20	4.217e-18	2.073e-16
45	Small cell carcinoma of lung	DOID:5409	16	4.413e-18	2.157e-16
46	Malignant neoplasm of esophagus	DOID:1104	16	5.429e-18	2.633e-16
47	Lymphoma	DOID:353	17	9.222e-18	4.349e-16
48	Esophageal Neoplasms	DOID:5041	16	1.468e-17	6.712e-16
49	Advanced Cancer	DOID:2337	13	1.704e-17	7.707e-16
50	Adenocarcinoma of Esophagus	DOID:4914	12	2.546e-17	1.129e-15
51	Hodgkin's disease, unspecified type	DOID:8567	15	4.208e-17	1.822e-15
52	Meningioma	DOID:3565	13	1.489e-16	5.951e-15
53	Carcinoma of Nasopharynx	DOID:9261	13	3.392e-16	1.287e-14
54	Adenocarcinoma of Lung	DOID:3910	14	7.470e-16	2.660e-14
55	Leukemia, Lymphocytic, chronic	DOID:1040	15	6.740e-15	2.111e-13
56	Thyroid carcinoma	DOID:3963	11	1.831e-14	5.404e-13
57	Malignant neoplasm of thyroid	DOID:10008	11	2.464e-14	7.138e-13
58	Adenovirus Infections	DOID:3124	12	2.797e-14	8.002e-13
59	Cholangiocarcinoma	DOID:4947	11	3.288e-14	9.251e-13
60	Prostatic Neoplasms	DOID:514	13	6.787e-14	1.806e-12
61	Neuroendocrine Tumors	DOID:169	9	9.056e-14	2.343e-12
62	Uterine Fibroids	DOID:13223	10	1.988e-13	4.820e-12
63	Liver neoplasms	DOID:3571	12	2.667e-13	6.288e-12
64	Systemic Scleroderma	DOID:418	13	3.372e-13	7.771e-12
65	Epithelial ovarian cancer	DOID:4001	10	4.869e-13	1.086e-11
66	Carcinoma of lung	DOID:3905	10	4.869e-13	1.086e-11
67	Endometriosis	DOID:289	15	7.106e-13	1.529e-11
68	Myeloid leukemia, chronic	DOID:8552	10	1.835e-12	3.626e-11
69	Disseminated Malignant Neoplasm	DOID:2332	9	2.920e-12	5.554e-11
70	Colorectal Neoplasms	DOID:1985	9	5.386e-12	9.720e-11
71	Sarcoma	DOID:1115	8	6.992e-12	1.233e-10
72	Pulmonary Emphysema	DOID:9675	8	1.042e-11	1.762e-10
73	Fibroid Tumor	DOID:127	9	1.251e-11	2.073e-10
74	Carcinoma in situ	DOID:8719	7	2.189e-11	3.450e-10
75	Cervix carcinoma	DOID:2893	9	2.694e-11	4.182e-10
76	Rheumatoid Arthritis	DOID:7148	18	3.472e-11	5.232e-10
77	Intraocular Melanoma	DOID:6039	8	4.282e-11	6.325e-10
78	Prostatic Hypertrophy, Benign	DOID:11131	9	6.793e-11	9.575e-10
79	Breast Cancer Stage IV	DOID:6267	9	6.793e-11	9.575e-10
80	Liver Metastases	DOID:12722	9	1.041e-10	1.412e-09
81	Colon Carcinoma	DOID:1520	10	1.339e-10	1.771e-09
82	acute leukemia	DOID:12603	9	2.303e-10	2.899e-09
83	Malignant neoplasm of mouth, unspecified	DOID:8894	9	2.303e-10	2.899e-09
84	Adenocarcinoma of the Pancreas	DOID:4074	9	2.777e-10	3.413e-09
85	Leukoencephalopathy, Progressive Multifocal	DOID:643	8	3.946e-10	4.678e-09
86	Stomach Neoplasms	DOID:4713	8	5.000e-10	5.806e-09
87	Laryngeal Squamous Cell Carcinoma	DOID:2876	7	6.272e-10	7.123e-09
88	Pancreatic carcinoma	DOID:4905	8	6.290e-10	7.141e-09
89	Malignant mesothelioma	DOID:1790	7	8.651e-10	9.528e-09
90	Herpangina	DOID:10883	7	1.176e-09	1.258e-08
91	Neoplasms, Epithelial	DOID:157	7	1.577e-09	1.631e-08
92	Astrocytoma	DOID:3069	9	1.988e-09	2.004e-08
93	Degenerative polyarthritis	DOID:455	10	2.195e-09	2.188e-08
94	Pituitary Adenoma	DOID:3829	7	2.733e-09	2.664e-08
95	Malignant Pleural Mesothelioma	DOID:7474	6	2.991e-09	2.888e-08
96	Obesity	DOID:9970	13	3.121e-09	2.990e-08
97	Gallbladder Carcinoma	DOID:4948	6	4.456e-09	4.122e-08
98	polyphagia	DOID:8669	7	4.543e-09	4.194e-08
99	Metastatic Melanoma	DOID:4358	7	7.281e-09	6.406e-08
100	Lung Neoplasms	DOID:3683	8	7.490e-09	6.558e-08
101	Malignant neoplasm of liver	DOID:12300	7	1.707e-08	1.357e-07
102	Esophageal carcinoma	DOID:1107	6	1.744e-08	1.380e-07
103	Carcinoma of bladder	DOID:4007	6	1.744e-08	1.380e-07
104	Ataxia Telangiectasia	DOID:12704	6	2.343e-08	1.786e-07
105	Malignant Squamous Cell Neoplasm	DOID:5512	5	2.501e-08	1.895e-07
106	Intraepithelial Neoplasia	DOID:5616	5	2.501e-08	1.895e-07
107	Rhabdomyosarcoma	DOID:3247	6	3.103e-08	2.298e-07
108	Malignant neoplasm of male breast	DOID:9796	4	6.186e-08	4.181e-07
109	Neoplasm, Thyroid	DOID:1781	6	6.689e-08	4.482e-07
110	Medulloblastoma	DOID:3858	7	7.127e-08	4.746e-07
111	Endometriosis of uterus	DOID:288	5	9.299e-08	5.961e-07
112	Seminoma	DOID:4440	5	9.299e-08	5.961e-07
113	Unspecified myeloid leukemia	DOID:8692	7	1.313e-07	8.060e-07
114	Kidney Neoplasms	DOID:263	5	1.344e-07	8.213e-07
115	Hepatoblastoma	DOID:687	5	1.891e-07	1.109e-06
116	Carcinoma, Endometrioid	DOID:3000	5	1.891e-07	1.109e-06
117	Congenital Abnormality	DOID:759	12	1.958e-07	1.143e-06
118	Neoplasm, Pancreatic	DOID:3588	6	1.980e-07	1.153e-06
119	Diabetes Mellitus, Non-Insulin-Dependent	DOID:9352	14	2.495e-07	1.416e-06
120	Mesothelioma	DOID:2645	5	2.601e-07	1.468e-06
121	Ductal Carcinoma	DOID:3007	7	3.380e-07	1.834e-06
122	Asthma	DOID:2841	10	4.143e-07	2.175e-06
123	Basal cell carcinoma	DOID:2513	6	4.143e-07	2.175e-06
124	Germ cell tumor	DOID:2994	5	4.646e-07	2.396e-06
125	Cystadenocarcinoma, Serous	DOID:3114	5	4.646e-07	2.396e-06
126	Lung Metastases	DOID:2158	5	4.646e-07	2.396e-06
127	Malignant neoplasm of testis	DOID:12231	4	5.098e-07	2.601e-06
128	acoustic neuroma	DOID:12689	4	5.098e-07	2.601e-06
129	Cervical Adenocarcinoma	DOID:3702	4	5.098e-07	2.601e-06
130	Dental Plaque	DOID:13598	7	6.145e-07	3.050e-06
131	Medullary carcinoma of thyroid	DOID:3973	5	1.241e-06	5.577e-06
132	Endometrial adenocarcinoma	DOID:2870	5	1.241e-06	5.577e-06
133	Alzheimer's disease	DOID:10652	11	1.318e-06	5.881e-06
134	Testicular dysfunction	DOID:11019	6	1.423e-06	6.285e-06
135	Dependence	DOID:9973	7	1.439e-06	6.349e-06
136	Fanconi's Anemia	DOID:13636	5	1.541e-06	6.734e-06
137	Infiltrating Malignant Neoplasm	DOID:8062	6	1.631e-06	7.075e-06
138	Nodular lymphoma	DOID:8524	5	1.895e-06	8.026e-06
139	Carcinoma of larynx	DOID:2600	4	1.965e-06	8.282e-06
140	Heart failure	DOID:6000	7	2.115e-06	8.827e-06
141	Fetal Growth Retardation	DOID:13294	5	2.310e-06	9.508e-06
142	Virus diseases	DOID:934	7	2.321e-06	9.548e-06
143	syndrome	DOID:225	11	2.354e-06	9.652e-06
144	Kaposi Sarcoma	DOID:8632	5	2.794e-06	1.120e-05
145	Bilateral Breast Cancer	DOID:6741	5	2.794e-06	1.120e-05
146	Secondary Carcinoma	DOID:4102	4	2.821e-06	1.129e-05
147	Gastrointestinal Stromal Tumors	DOID:9253	5	3.354e-06	1.305e-05
148	Sarcoma, Synovial	DOID:5485	4	3.924e-06	1.490e-05
149	Barrett's esophagus	DOID:9206	5	3.999e-06	1.514e-05
150	Rabies	DOID:11260	7	4.276e-06	1.601e-05
151	Primary biliary cirrhosis	DOID:12236	5	4.737e-06	1.746e-05
152	Cytomegalovirus Infections	DOID:11259	4	5.317e-06	1.919e-05
153	Adenoid Cystic Carcinoma	DOID:4866	4	5.317e-06	1.919e-05
154	Papillary thyroid carcinoma	DOID:3969	5	5.577e-06	1.998e-05
155	mental depression	DOID:1596	6	6.041e-06	2.142e-05
156	Bladder Neoplasm	DOID:5428	5	7.606e-06	2.595e-05
157	Burkitt's tumor or lymphoma	DOID:8584	4	9.154e-06	3.049e-05
158	Adenoma of Parathyroid	DOID:7608	3	1.030e-05	3.371e-05
159	Parathyroid Neoplasms	DOID:11006	3	1.030e-05	3.371e-05
160	Adenocarcinoma of Rectum	DOID:1996	3	1.030e-05	3.371e-05
161	Parkinson disease	DOID:14330	7	1.074e-05	3.484e-05
162	dementia	DOID:1307	5	1.168e-05	3.735e-05
163	Brain Neoplasms	DOID:1319	5	1.337e-05	4.179e-05
164	autoimmune disease	DOID:417	6	1.447e-05	4.449e-05
165	Nephroblastoma	DOID:2154	4	1.828e-05	5.407e-05
166	Epstein-Barr Virus Infections	DOID:2938	4	2.244e-05	6.433e-05
167	Pancreatitis, relapsing	DOID:13315	4	2.244e-05	6.433e-05
168	Hypertension	DOID:10763	8	2.458e-05	6.941e-05
169	Pituitary Neoplasms	DOID:1785	4	2.726e-05	7.571e-05
170	Anaplastic Meningioma	DOID:5613	3	2.850e-05	7.827e-05
171	Breast diseases	DOID:3463	3	2.850e-05	7.827e-05
172	Leukemia, Lymphocytic, acute	DOID:9952	5	3.108e-05	8.434e-05
173	Pre-Eclampsia	DOID:10591	7	3.215e-05	8.659e-05
174	Diabetic Retinopathy	DOID:8947	5	3.464e-05	9.217e-05
175	Leiomyosarcoma	DOID:1967	3	4.249e-05	1.083e-04
176	Fibroadenoma	DOID:2693	3	4.249e-05	1.083e-04
177	Graves' disease	DOID:12361	5	5.216e-05	1.283e-04
178	Spontaneous abortion	DOID:722	5	6.315e-05	1.498e-04
179	Carcinoma, Papillary	DOID:3113	4	6.336e-05	1.502e-04
180	Adenocarcinoma of the Colon	DOID:234	4	7.345e-05	1.690e-04
181	Adenocarcinoma of Prostate	DOID:2526	4	7.345e-05	1.690e-04
182	Glaucoma	DOID:1686	4	7.345e-05	1.690e-04
183	Colonic Neoplasms	DOID:235	4	7.345e-05	1.690e-04
184	Amyotrophic Lateral Sclerosis	DOID:332	5	7.585e-05	1.733e-04
185	Proliferative diabetic retinopathy	DOID:13207	3	8.247e-05	1.855e-04
186	Ewings sarcoma	DOID:3369	4	8.467e-05	1.900e-04
187	Atherosclerosis	DOID:1936	7	8.879e-05	1.968e-04
188	Neck Neoplasms	DOID:4725	3	1.093e-04	2.328e-04
189	Acquired Immunodeficiency syndrome	DOID:635	4	1.258e-04	2.614e-04
190	Ependymoma	DOID:4844	3	1.412e-04	2.877e-04
191	thyroid gland disease	DOID:50	3	1.412e-04	2.877e-04
192	Hereditary Nonpolyposis Colorectal Neoplasms	DOID:3040	3	1.787e-04	3.478e-04
193	Cancer of Rectum	DOID:1993	3	1.787e-04	3.478e-04
194	Yersinia infections	DOID:3300	5	1.844e-04	3.578e-04
195	Tuberculosis	DOID:399	5	2.128e-04	4.011e-04
196	Lymphatic Metastasis	DOID:4100	3	2.220e-04	4.150e-04
197	Osteoporosis	DOID:11476	4	3.039e-04	5.351e-04
198	Periodontitis	DOID:824	4	3.676e-04	6.256e-04
199	psychotic disorders	DOID:2468	3	3.911e-04	6.579e-04
200	Malignant neoplasm of gallbladder	DOID:8090	3	3.911e-04	6.579e-04
201	Neurodegenerative disorders	DOID:4874	4	4.028e-04	6.737e-04
202	Hepatitis C, chronic	DOID:2049	4	4.402e-04	7.250e-04
203	Hypertension induced by pregnancy	DOID:12684	6	5.281e-04	8.432e-04
204	Systemic lupus erythematosus	DOID:9074	6	5.992e-04	9.347e-04
205	Dermatitis, Atopic	DOID:3310	5	6.090e-04	9.478e-04
206	Cerebral Infarction	DOID:3526	3	6.262e-04	9.684e-04
207	Cerebrovascular accident	DOID:3455	5	6.429e-04	9.891e-04
208	Polyp of corpus uteri	DOID:9042	2	6.437e-04	9.896e-04
209	Seemanova syndrome II	DOID:7400	2	6.437e-04	9.896e-04
210	Childhood Solid Tumor	DOID:6341	2	6.437e-04	9.896e-04
211	Plasmacytoma	DOID:3721	2	6.437e-04	9.896e-04
212	Endometrial Hyperplasia	DOID:8835	2	6.437e-04	9.896e-04
213	Urticaria Pigmentosa	DOID:12309	2	6.437e-04	9.896e-04
214	Mastocytosis	DOID:350	2	6.437e-04	9.896e-04
215	Mucoepidermoid Carcinoma	DOID:4531	2	6.437e-04	9.896e-04
216	Ganglioglioma	DOID:5078	2	6.437e-04	9.896e-04
217	Localized Malignant Neoplasm	DOID:11933	2	6.437e-04	9.896e-04
218	Infertility	DOID:5223	4	7.755e-04	1.153e-03
219	Ulcerative colitis, unspecified	DOID:8577	5	9.210e-04	1.330e-03
220	Anaplastic astrocytoma	DOID:3078	2	9.605e-04	1.375e-03
221	Carcinoma, Large Cell	DOID:4552	2	9.605e-04	1.375e-03
222	Rhabdoid Tumor	DOID:3672	2	9.605e-04	1.375e-03
223	Degenerative disc disease NOS	DOID:89	2	9.605e-04	1.375e-03
224	Synovitis	DOID:2703	2	9.605e-04	1.375e-03
225	disease of capillaries	DOID:1271	2	9.605e-04	1.375e-03
226	Ischemia	DOID:326	4	1.105e-03	1.546e-03
227	Coronary Arteriosclerosis	DOID:3363	6	1.113e-03	1.556e-03
228	Lupus Vulgaris	DOID:5380	3	1.188e-03	1.640e-03
229	Pulmonary Fibrosis	DOID:3770	3	1.329e-03	1.799e-03
230	Solid Tumor	DOID:5650	3	1.329e-03	1.799e-03
231	Sarcoma, Clear Cell	DOID:4233	2	1.337e-03	1.807e-03
232	Silicosis	DOID:10325	2	1.337e-03	1.807e-03
233	Uterine Cancer	DOID:4363	2	1.337e-03	1.807e-03
234	Lymphopenia	DOID:614	2	1.337e-03	1.807e-03
235	Liver Failure, acute	DOID:4721	2	1.337e-03	1.807e-03
236	Adrenocortical carcinoma	DOID:3948	2	1.337e-03	1.807e-03
237	Werner syndrome	DOID:5688	2	1.337e-03	1.807e-03
238	Myoma	DOID:2691	2	1.337e-03	1.807e-03
239	Primary CNS Lymphoma	DOID:3233	2	1.337e-03	1.807e-03
240	Squamous cell carcinoma of skin	DOID:3151	2	1.774e-03	2.299e-03
241	Malignant Fibroxanthoma	DOID:1907	2	1.774e-03	2.299e-03
242	Lichen planus	DOID:9201	2	1.774e-03	2.299e-03
243	HIV Infections	DOID:526	5	1.807e-03	2.336e-03
244	Lupus erythematosus	DOID:8857	3	1.812e-03	2.343e-03
245	Diabetic Nephropathy	DOID:2370	4	2.152e-03	2.714e-03
246	Osteomyelitis	DOID:1019	2	2.268e-03	2.842e-03
247	Carcinoma, Lobular	DOID:3457	2	2.268e-03	2.842e-03
248	Ptosis	DOID:9308	2	2.268e-03	2.842e-03
249	Malignant neoplasm of brain	DOID:911	2	2.268e-03	2.842e-03
250	Stage I NSCLC	DOID:4820	2	2.268e-03	2.842e-03
251	Celiac disease	DOID:10608	3	2.608e-03	3.197e-03
252	Adenocarcinoma, Mucinous	DOID:3030	2	2.821e-03	3.425e-03
253	Liver Cirrhosis	DOID:5082	3	2.836e-03	3.442e-03
254	Multiple Sclerosis	DOID:2377	5	3.428e-03	4.053e-03
255	Multiple malignancy	DOID:9260	2	3.429e-03	4.053e-03
256	Rett syndrome	DOID:1206	2	3.429e-03	4.053e-03
257	Atrophic condition of skin	DOID:2733	2	3.429e-03	4.053e-03
258	Pilocytic Astrocytoma	DOID:4851	2	3.429e-03	4.053e-03
259	Dermatomyositis	DOID:10223	2	3.429e-03	4.053e-03
260	Thrombocythemia, Hemorrhagic	DOID:2224	2	3.429e-03	4.053e-03
261	chronic Obstructive Airway disease	DOID:3083	4	3.738e-03	4.385e-03
262	Hamman-Rich syndrome	DOID:2797	3	3.867e-03	4.520e-03
263	esotropia	DOID:9840	2	4.093e-03	4.757e-03
264	Bone diseases	DOID:1290	2	4.093e-03	4.757e-03
265	Fatty Liver	DOID:9452	2	4.093e-03	4.757e-03
266	Hypoglycemia	DOID:9993	2	4.811e-03	5.489e-03
267	Cancer of Skin	DOID:4159	2	4.811e-03	5.489e-03
268	Neurilemmoma	DOID:3192	2	4.811e-03	5.489e-03
269	Arthritis	DOID:848	3	5.100e-03	5.787e-03
270	Epilepsy, Temporal Lobe	DOID:3328	2	5.584e-03	6.274e-03
271	Oligodendroglioma	DOID:3181	2	5.584e-03	6.274e-03
272	Cystic Fibrosis	DOID:1485	3	6.163e-03	6.878e-03
273	Polymyositis	DOID:10222	2	7.285e-03	7.994e-03
274	Bacterial Infections	DOID:104	2	7.285e-03	7.994e-03
275	Skin Neoplasms	DOID:3165	2	7.285e-03	7.994e-03
276	chronic rejection of renal transplant	DOID:2985	2	7.285e-03	7.994e-03
277	Leukemia, T-Cell	DOID:715	2	7.285e-03	7.994e-03
278	Chondrosarcoma	DOID:3371	2	8.213e-03	8.912e-03
279	Skin Melanoma	DOID:8923	2	8.213e-03	8.912e-03
280	Kidney Failure, chronic	DOID:784	2	9.190e-03	9.904e-03
281	Uremia	DOID:4676	2	9.190e-03	9.904e-03
282	Diabetes Mellitus	DOID:9351	4	9.273e-03	9.990e-03
283	Spinal Dysraphism	DOID:1089	2	1.022e-02	1.093e-02
284	Helicobacter Infections	DOID:3686	2	1.022e-02	1.093e-02
285	Malignant neoplasm of kidney	DOID:3676	2	1.129e-02	1.200e-02
286	chronic simple glaucoma	DOID:1070	2	1.129e-02	1.200e-02
287	Anemia	DOID:2355	2	1.242e-02	1.312e-02
288	Hepatitis	DOID:2237	2	1.242e-02	1.312e-02
289	Vitiligo	DOID:12306	2	1.242e-02	1.312e-02
290	Pancreatitis	DOID:4989	2	1.242e-02	1.312e-02
291	Huntington disease	DOID:12858	2	1.242e-02	1.312e-02
292	Severe acute Respiratory syndrome	DOID:2945	2	1.242e-02	1.312e-02
293	Coronary heart disease	DOID:3393	3	1.280e-02	1.350e-02
294	Kidney Failure	DOID:1074	2	1.358e-02	1.430e-02
295	Scleroderma	DOID:419	2	1.358e-02	1.430e-02
296	Polycystic Ovary syndrome	DOID:11612	3	1.586e-02	1.656e-02
297	Cholelithiasis	DOID:10211	2	1.606e-02	1.676e-02
298	Bone Metastases	DOID:2759	2	1.606e-02	1.676e-02
299	Infertility, Male	DOID:12336	2	1.606e-02	1.676e-02
300	Myelofibrosis	DOID:4971	2	1.606e-02	1.676e-02
301	Sickle Cell Anemia	DOID:10923	2	2.010e-02	2.078e-02
302	pneumonia	DOID:552	2	2.154e-02	2.220e-02
303	Diabetes, Gestational	DOID:11714	2	2.301e-02	2.365e-02
304	Vascular diseases	DOID:178	2	2.301e-02	2.365e-02
305	Systemic infection	DOID:2288	3	2.394e-02	2.458e-02
306	schizophrenia	DOID:5419	5	2.419e-02	2.482e-02
307	Down syndrome	DOID:14250	3	2.477e-02	2.538e-02
308	Myopathy	DOID:423	2	2.767e-02	2.827e-02
309	Liver diseases	DOID:409	2	2.930e-02	2.989e-02
310	Rheumatism	DOID:4256	2	3.267e-02	3.321e-02
311	Retinal diseases	DOID:5679	2	3.267e-02	3.321e-02
312	Sarcoidosis	DOID:11335	2	3.619e-02	3.671e-02
313	malaria	DOID:12365	2	3.800e-02	3.849e-02
314	End stage renal failure	DOID:783	2	4.956e-02	4.998e-02

- KEGG pathway/disease terms

#	Description	Term ID	# of overlapped genes	P value	FDR

1	p53 signaling pathway	hsa04115	31	2.401e-47	8.405e-44
2	Pathways in cancer	hsa05200	46	4.159e-40	4.368e-37
3	Hepatitis B	hsa05161	29	3.347e-32	6.509e-30
4	Prostate cancer	hsa05215	24	3.262e-30	5.270e-28
5	Cell cycle	hsa04110	25	5.348e-28	6.850e-26
6	HTLV-I infection	hsa05166	28	1.518e-23	1.340e-21
7	Bladder cancer	hsa05219	16	2.323e-23	2.016e-21
8	Pancreatic cancer	hsa05212	17	2.923e-21	2.257e-19
9	FoxO signaling pathway	hsa04068	21	3.154e-21	2.393e-19
10	PI3K-Akt signaling pathway	hsa04151	29	3.168e-21	2.393e-19
11	Chronic myeloid leukemia	hsa05220	17	1.896e-20	1.345e-18
12	MicroRNAs in cancer	hsa05206	26	1.559e-19	1.043e-17
13	Small cell lung cancer	hsa05222	17	3.735e-19	2.378e-17
14	Melanoma	hsa05218	16	4.664e-19	2.933e-17
15	Viral carcinogenesis	hsa05203	21	2.496e-17	1.351e-15
16	Glioma	hsa05214	14	1.642e-16	7.947e-15
17	Proteoglycans in cancer	hsa05205	20	3.221e-16	1.477e-14
18	Measles	hsa05162	16	1.688e-14	6.401e-13
19	Transcriptional misregulation in cancer	hsa05202	17	1.118e-13	3.590e-12
20	Apoptosis	hsa04210	13	2.132e-13	6.545e-12
21	Epstein-Barr virus infection	hsa05169	17	6.859e-13	1.926e-11
22	Non-small cell lung cancer	hsa05223	11	9.566e-13	2.630e-11
23	Acute myeloid leukemia	hsa05221	11	1.172e-12	3.151e-11
24	Colorectal cancer	hsa05210	11	3.062e-12	7.584e-11
25	Endometrial cancer	hsa05213	10	1.355e-11	2.952e-10
26	HIF-1 signaling pathway	hsa04066	12	4.925e-11	9.651e-10
27	Progesterone-mediated oocyte maturation	hsa04914	11	1.337e-10	2.392e-09
28	Hippo signaling pathway	hsa04390	13	4.319e-10	6.759e-09
29	Ras signaling pathway	hsa04014	15	5.746e-10	8.772e-09
30	Focal adhesion	hsa04510	14	1.641e-09	2.255e-08
31	Central carbon metabolism in cancer	hsa05230	9	3.999e-09	4.965e-08
32	Prolactin signaling pathway	hsa04917	9	7.611e-09	8.822e-08
33	Rap1 signaling pathway	hsa04015	13	1.960e-08	2.071e-07
34	MAPK signaling pathway	hsa04010	14	2.340e-08	2.407e-07
35	Toxoplasmosis	hsa05145	10	4.674e-08	4.387e-07
36	Thyroid hormone signaling pathway	hsa04919	10	4.674e-08	4.387e-07
37	Sphingolipid signaling pathway	hsa04071	10	5.481e-08	5.023e-07
38	Jak-STAT signaling pathway	hsa04630	11	7.359e-08	6.538e-07
39	Adipocytokine signaling pathway	hsa04920	8	1.091e-07	9.275e-07
40	Thyroid cancer	hsa05216	6	1.315e-07	1.090e-06
41	Hepatitis C	hsa05160	10	1.443e-07	1.176e-06
42	Amyotrophic lateral sclerosis (ALS)	hsa05014	7	2.003e-07	1.587e-06
43	Signaling pathways regulating pluripotency of stem cells	hsa04550	10	2.656e-07	2.036e-06
44	Insulin resistance	hsa04931	9	2.819e-07	2.142e-06
45	Legionellosis	hsa05134	7	3.380e-07	2.523e-06
46	Neurotrophin signaling pathway	hsa04722	9	6.355e-07	4.343e-06
47	AMPK signaling pathway	hsa04152	9	8.368e-07	5.499e-06
48	Influenza A	hsa05164	10	1.792e-06	1.047e-05
49	Tuberculosis	hsa05152	10	1.984e-06	1.141e-05
50	Herpes simplex infection	hsa05168	10	2.808e-06	1.521e-05
51	NOD-like receptor signaling pathway	hsa04621	6	7.431e-06	3.465e-05
52	Epithelial cell signaling in Helicobacter pylori infection	hsa05120	6	2.045e-05	8.218e-05
53	Wnt signaling pathway	hsa04310	8	2.114e-05	8.453e-05
54	Chagas disease (American trypanosomiasis)	hsa05142	7	2.378e-05	9.348e-05
55	Adherens junction	hsa04520	6	3.056e-05	1.153e-04
56	TNF signaling pathway	hsa04668	7	3.408e-05	1.259e-04
57	Oocyte meiosis	hsa04114	7	3.823e-05	1.385e-04
58	ErbB signaling pathway	hsa04012	6	8.143e-05	2.619e-04
59	Ubiquitin mediated proteolysis	hsa04120	7	1.354e-04	3.945e-04
60	Chemokine signaling pathway	hsa04062	8	1.531e-04	4.352e-04
61	Estrogen signaling pathway	hsa04915	6	1.653e-04	4.624e-04
62	Inflammatory bowel disease (IBD)	hsa05321	5	1.982e-04	5.320e-04
63	Renal cell carcinoma	hsa05211	5	2.128e-04	5.641e-04
64	T cell receptor signaling pathway	hsa04660	6	2.159e-04	5.703e-04
65	Non-alcoholic fatty liver disease (NAFLD)	hsa04932	7	2.459e-04	6.333e-04
66	Endocytosis	hsa04144	9	2.731e-04	6.844e-04
67	B cell receptor signaling pathway	hsa04662	5	3.183e-04	7.711e-04
68	Nucleotide excision repair	hsa03420	4	6.154e-04	1.303e-03
69	TGF-beta signaling pathway	hsa04350	5	6.429e-04	1.352e-03
70	NF-kappa B signaling pathway	hsa04064	5	9.210e-04	1.802e-03
71	Basal cell carcinoma	hsa05217	4	1.105e-03	2.083e-03
72	Cytokine-cytokine receptor interaction	hsa04060	8	1.513e-03	2.676e-03
73	Toll-like receptor signaling pathway	hsa04620	5	1.807e-03	3.093e-03
74	Homologous recombination	hsa03440	3	1.812e-03	3.101e-03
75	Cytosolic DNA-sensing pathway	hsa04623	4	1.924e-03	3.249e-03
76	Pertussis	hsa05133	4	3.404e-03	5.140e-03
77	Osteoclast differentiation	hsa04380	5	4.473e-03	6.414e-03
78	Natural killer cell mediated cytotoxicity	hsa04650	5	4.918e-03	6.960e-03
79	Huntington's disease	hsa05016	6	5.099e-03	7.173e-03
80	Salmonella infection	hsa05132	4	5.515e-03	7.646e-03
81	Tight junction	hsa04530	5	5.558e-03	7.700e-03
82	Gap junction	hsa04540	4	5.974e-03	8.176e-03
83	Regulation of actin cytoskeleton	hsa04810	6	8.295e-03	1.079e-02
84	Choline metabolism in cancer	hsa05231	4	9.592e-03	1.225e-02
85	Glucagon signaling pathway	hsa04922	4	9.592e-03	1.225e-02
86	Oxytocin signaling pathway	hsa04921	5	9.663e-03	1.233e-02
87	Pyrimidine metabolism	hsa00240	4	1.094e-02	1.370e-02
88	Amoebiasis	hsa05146	4	1.202e-02	1.488e-02
89	Viral myocarditis	hsa05416	3	1.223e-02	1.511e-02
90	mTOR signaling pathway	hsa04150	3	1.338e-02	1.634e-02
91	Serotonergic synapse	hsa04726	4	1.358e-02	1.657e-02
92	VEGF signaling pathway	hsa04370	3	1.398e-02	1.700e-02
93	Shigellosis	hsa05131	3	1.652e-02	1.970e-02
94	RIG-I-like receptor signaling pathway	hsa04622	3	2.004e-02	2.336e-02
95	Leishmaniasis	hsa05140	3	2.155e-02	2.494e-02
96	Bacterial invasion of epithelial cells	hsa05100	3	2.646e-02	2.996e-02
97	Insulin signaling pathway	hsa04910	4	2.737e-02	3.091e-02
98	Phospholipase D signaling pathway	hsa04072	4	2.993e-02	3.351e-02
99	Base excision repair	hsa03410	2	3.097e-02	3.459e-02
100	Prion diseases	hsa05020	2	3.442e-02	3.810e-02
101	DNA replication	hsa03030	2	3.619e-02	3.998e-02
102	Rheumatoid arthritis	hsa05323	3	3.688e-02	4.066e-02
103	GnRH signaling pathway	hsa04912	3	3.897e-02	4.281e-02

- Gene Ontology biological process terms

#	Description	Term ID	# of overlapped genes	P value	FDR

1	apoptotic process	GO:0006915	37	3.088e-22	1.921e-19
2	positive regulation of transcription, DNA-dependent	GO:0045893	31	9.974e-20	4.366e-17
3	response to DNA damage stimulus	GO:0006974	19	2.609e-19	9.638e-17
4	negative regulation of apoptotic process	GO:0043066	23	1.521e-17	4.552e-15
5	positive regulation of transcription from RNA polymerase II promoter	GO:0045944	30	3.091e-16	7.234e-14
6	negative regulation of transcription from RNA polymerase II promoter	GO:0000122	26	6.427e-16	1.394e-13
7	induction of apoptosis by intracellular signals	GO:0008629	12	9.132e-16	1.927e-13
8	positive regulation of cell proliferation	GO:0008284	24	1.454e-15	2.945e-13
9	negative regulation of cell proliferation	GO:0008285	23	3.998e-15	7.443e-13
10	DNA repair	GO:0006281	21	1.672e-14	2.725e-12
11	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919	13	1.915e-14	3.079e-12
12	G2/M transition of mitotic cell cycle	GO:0000086	15	2.707e-14	4.211e-12
13	release of cytochrome c from mitochondria	GO:0001836	9	5.551e-14	7.857e-12
14	mitotic cell cycle	GO:0000278	21	1.546e-13	2.008e-11
15	cell cycle checkpoint	GO:0000075	15	1.720e-13	2.175e-11
16	cell cycle arrest	GO:0007050	15	1.720e-13	2.175e-11
17	response to drug	GO:0042493	20	1.836e-13	2.309e-11
18	cellular response to hypoxia	GO:0071456	10	4.869e-13	5.642e-11
19	anti-apoptosis	GO:0006916	17	6.859e-13	7.652e-11
20	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	GO:0042771	8	1.834e-12	1.875e-10
21	activation of pro-apoptotic gene products	GO:0008633	9	2.920e-12	2.865e-10
22	G1/S transition of mitotic cell cycle	GO:0000082	14	1.333e-11	1.094e-09
23	negative regulation of mitotic cell cycle	GO:0045930	7	2.189e-11	1.714e-09
24	induction of apoptosis	GO:0006917	15	2.385e-11	1.855e-09
25	response to gamma radiation	GO:0010332	8	4.282e-11	3.068e-09
26	cell cycle	GO:0007049	20	3.698e-10	2.047e-08
27	regulation of cyclin-dependent protein kinase activity	GO:0000079	9	3.990e-10	2.167e-08
28	negative regulation of transcription, DNA-dependent	GO:0045892	19	5.101e-10	2.668e-08
29	cell proliferation	GO:0008283	17	6.213e-10	3.166e-08
30	regulation of apoptotic process	GO:0042981	14	7.059e-10	3.525e-08
31	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	6	7.405e-10	3.639e-08
32	positive regulation of anti-apoptosis	GO:0045768	8	7.859e-10	3.839e-08
33	cell aging	GO:0007569	7	8.651e-10	4.182e-08
34	positive regulation of apoptotic process	GO:0043065	13	1.171e-09	5.354e-08
35	regulation of cell cycle	GO:0051726	9	1.988e-09	8.379e-08
36	Ras protein signal transduction	GO:0007265	9	5.920e-09	2.140e-07
37	cellular response to mechanical stimulus	GO:0071260	8	7.490e-09	2.581e-07
38	phosphatidylinositol-mediated signaling	GO:0048015	9	8.605e-09	2.910e-07
39	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	GO:0008635	5	1.469e-08	4.574e-07
40	negative regulation of cell growth	GO:0030308	10	2.393e-08	6.800e-07
41	G1 phase of mitotic cell cycle	GO:0000080	7	2.516e-08	7.082e-07
42	response to cytokine stimulus	GO:0034097	8	2.829e-08	7.758e-07
43	positive regulation of mitotic cell cycle	GO:0045931	6	4.056e-08	1.050e-06
44	interspecies interaction between organisms	GO:0044419	15	4.373e-08	1.124e-06
45	response to toxin	GO:0009636	8	7.736e-08	1.769e-06
46	mammary gland alveolus development	GO:0060749	5	9.299e-08	2.051e-06
47	organ regeneration	GO:0031100	7	1.516e-07	3.051e-06
48	nerve growth factor receptor signaling pathway	GO:0048011	12	1.958e-07	3.783e-06
49	S phase of mitotic cell cycle	GO:0000084	9	3.289e-07	5.808e-06
50	response to X-ray	GO:0010165	5	3.507e-07	6.146e-06
51	DNA replication	GO:0006260	10	4.143e-07	7.007e-06
52	response to UV	GO:0009411	6	4.143e-07	7.007e-06
53	DNA damage response, signal transduction resulting in induction of apoptosis	GO:0008630	5	4.646e-07	7.659e-06
54	mitotic cell cycle G1/S transition DNA damage checkpoint	GO:0031571	4	5.098e-07	8.249e-06
55	replicative senescence	GO:0090399	4	5.098e-07	8.249e-06
56	fibroblast growth factor receptor signaling pathway	GO:0008543	9	5.135e-07	8.304e-06
57	cell division	GO:0051301	13	5.398e-07	8.663e-06
58	response to estrogen stimulus	GO:0043627	7	5.477e-07	8.725e-06
59	positive regulation of fibroblast proliferation	GO:0048146	6	6.802e-07	1.046e-05
60	positive regulation of reactive oxygen species metabolic process	GO:2000379	5	7.788e-07	1.151e-05
61	regulation of mitochondrial membrane permeability	GO:0046902	4	8.443e-07	1.224e-05
62	cellular response to interleukin-1	GO:0071347	5	9.886e-07	1.392e-05
63	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:0035872	6	1.072e-06	1.482e-05
64	in utero embryonic development	GO:0001701	10	1.112e-06	1.524e-05
65	epidermal growth factor receptor signaling pathway	GO:0007173	9	1.164e-06	1.576e-05
66	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	7	1.176e-06	1.590e-05
67	nucleotide-excision repair	GO:0006289	7	1.176e-06	1.590e-05
68	positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	4	1.965e-06	2.350e-05
69	response to cAMP	GO:0051591	6	2.409e-06	2.751e-05
70	protein complex assembly	GO:0006461	8	3.214e-06	3.416e-05
71	positive regulation of blood vessel endothelial cell migration	GO:0043536	4	3.924e-06	3.957e-05
72	induction of apoptosis via death domain receptors	GO:0008625	4	5.317e-06	5.008e-05
73	response to estradiol stimulus	GO:0032355	7	5.457e-06	5.116e-05
74	response to ethanol	GO:0045471	7	5.907e-06	5.455e-05
75	negative regulation of protein catabolic process	GO:0042177	4	7.044e-06	6.186e-05
76	osteoblast development	GO:0002076	4	7.044e-06	6.186e-05
77	protein stabilization	GO:0050821	6	7.431e-06	6.392e-05
78	lactation	GO:0007595	5	7.606e-06	6.501e-05
79	positive regulation of DNA replication	GO:0045740	5	7.606e-06	6.501e-05
80	cellular response to organic cyclic compound	GO:0071407	5	8.816e-06	7.295e-05
81	negative regulation of cyclin-dependent protein kinase activity	GO:0045736	4	9.154e-06	7.525e-05
82	response to hypoxia	GO:0001666	9	9.609e-06	7.756e-05
83	centrosome cycle	GO:0007098	3	1.030e-05	8.165e-05
84	negative regulation of stress-activated MAPK cascade	GO:0032873	3	1.030e-05	8.165e-05
85	phosphorylation	GO:0016310	5	1.168e-05	8.968e-05
86	T cell homeostasis	GO:0043029	4	1.169e-05	8.970e-05
87	chromosome organization	GO:0051276	4	1.169e-05	8.970e-05
88	protein destabilization	GO:0031648	4	1.472e-05	1.063e-04
89	cellular response to ionizing radiation	GO:0071479	4	1.472e-05	1.063e-04
90	positive regulation of smooth muscle cell proliferation	GO:0048661	5	1.523e-05	1.093e-04
91	mammary gland epithelial cell proliferation	GO:0033598	3	1.792e-05	1.235e-04
92	negative regulation of fibroblast proliferation	GO:0048147	4	1.828e-05	1.249e-04
93	regulation of transcription involved in G1/S phase of mitotic cell cycle	GO:0000083	4	1.828e-05	1.249e-04
94	neuron apoptosis	GO:0051402	4	1.828e-05	1.249e-04
95	response to inorganic substance	GO:0010035	4	1.828e-05	1.249e-04
96	positive regulation of cell migration	GO:0030335	7	1.969e-05	1.320e-04
97	liver development	GO:0001889	6	2.410e-05	1.530e-04
98	androgen receptor signaling pathway	GO:0030521	5	2.481e-05	1.561e-04
99	regulation of angiogenesis	GO:0045765	4	2.726e-05	1.673e-04
100	cellular response to organic substance	GO:0071310	3	2.850e-05	1.724e-04
101	response to UV-C	GO:0010225	3	2.850e-05	1.724e-04
102	response to mechanical stimulus	GO:0009612	5	3.108e-05	1.840e-04
103	negative regulation of neuron apoptosis	GO:0043524	6	3.559e-05	2.017e-04
104	negative regulation of cell cycle arrest	GO:0071157	3	4.249e-05	2.284e-04
105	DNA damage response, signal transduction by p53 class mediator	GO:0030330	3	4.249e-05	2.284e-04
106	negative regulation of protein kinase activity	GO:0006469	5	4.271e-05	2.292e-04
107	forebrain development	GO:0030900	5	5.216e-05	2.648e-04
108	protein kinase B signaling cascade	GO:0043491	4	5.431e-05	2.722e-04
109	mammary gland development	GO:0030879	4	5.431e-05	2.722e-04
110	G2 phase of mitotic cell cycle	GO:0000085	3	6.034e-05	2.940e-04
111	regulation of mitochondrial membrane potential	GO:0051881	3	6.034e-05	2.940e-04
112	response to nutrient	GO:0007584	6	6.273e-05	3.012e-04
113	spermatogenesis	GO:0007283	11	6.312e-05	3.025e-04
114	response to radiation	GO:0009314	4	6.336e-05	3.036e-04
115	developmental growth	GO:0048589	4	6.336e-05	3.036e-04
116	response to calcium ion	GO:0051592	5	6.928e-05	3.235e-04
117	regulation of mitotic cell cycle	GO:0007346	4	7.345e-05	3.361e-04
118	negative regulation of protein phosphorylation	GO:0001933	4	7.345e-05	3.361e-04
119	response to antibiotic	GO:0046677	4	7.345e-05	3.361e-04
120	negative regulation of sequence-specific DNA binding transcription factor activity	GO:0043433	5	7.585e-05	3.430e-04
121	cellular response to glucose starvation	GO:0042149	3	8.247e-05	3.646e-04
122	cellular senescence	GO:0090398	3	8.247e-05	3.646e-04
123	positive regulation of mesenchymal cell proliferation	GO:0002053	4	8.467e-05	3.727e-04
124	cellular response to tumor necrosis factor	GO:0071356	4	8.467e-05	3.727e-04
125	cytokinesis	GO:0000910	5	9.043e-05	3.903e-04
126	positive regulation of nitric oxide biosynthetic process	GO:0045429	4	1.108e-04	4.514e-04
127	positive regulation of MAP kinase activity	GO:0043406	4	1.108e-04	4.514e-04
128	mitosis	GO:0007067	8	1.225e-04	4.815e-04
129	branching involved in ureteric bud morphogenesis	GO:0001658	4	1.258e-04	4.922e-04
130	response to organic nitrogen	GO:0010243	4	1.258e-04	4.922e-04
131	organ morphogenesis	GO:0009887	6	1.321e-04	5.101e-04
132	mammary gland epithelial cell differentiation	GO:0060644	3	1.412e-04	5.333e-04
133	insulin receptor signaling pathway	GO:0008286	7	1.417e-04	5.344e-04
134	base-excision repair	GO:0006284	4	1.602e-04	5.815e-04
135	hemopoiesis	GO:0030097	5	1.713e-04	6.118e-04
136	response to virus	GO:0009615	7	1.763e-04	6.233e-04
137	response to growth factor stimulus	GO:0070848	3	1.787e-04	6.277e-04
138	endoderm formation	GO:0001706	3	1.787e-04	6.277e-04
139	positive regulation of cardiac muscle cell proliferation	GO:0060045	3	1.787e-04	6.277e-04
140	oocyte maturation	GO:0001556	3	1.787e-04	6.277e-04
141	positive regulation of peptidyl-serine phosphorylation	GO:0033138	4	1.797e-04	6.302e-04
142	response to organic cyclic compound	GO:0014070	6	1.843e-04	6.437e-04
143	positive regulation of gene expression	GO:0010628	6	1.843e-04	6.437e-04
144	canonical Wnt receptor signaling pathway	GO:0060070	5	1.844e-04	6.439e-04
145	heart development	GO:0007507	7	2.003e-04	6.800e-04
146	positive regulation of angiogenesis	GO:0045766	5	2.128e-04	7.095e-04
147	digestive tract morphogenesis	GO:0048546	3	2.220e-04	7.315e-04
148	positive regulation of cell cycle arrest	GO:0071158	3	2.220e-04	7.315e-04
149	negative regulation of protein kinase B signaling cascade	GO:0051898	3	2.717e-04	8.491e-04
150	cellular response to lithium ion	GO:0071285	3	2.717e-04	8.491e-04
151	positive regulation of neuron apoptosis	GO:0043525	4	2.753e-04	8.575e-04
152	activation of MAPKK activity	GO:0000186	4	3.347e-04	9.848e-04
153	innate immune response	GO:0045087	10	3.489e-04	1.014e-03
154	kidney development	GO:0001822	5	3.610e-04	1.039e-03
155	regulation of nitric-oxide synthase activity	GO:0050999	3	4.617e-04	1.240e-03
156	regulation of phosphorylation	GO:0042325	3	4.617e-04	1.240e-03
157	negative regulation of protein binding	GO:0032091	3	4.617e-04	1.240e-03
158	positive regulation of epithelial cell proliferation	GO:0050679	4	4.802e-04	1.276e-03
159	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:0031145	5	4.867e-04	1.289e-03
160	positive regulation of protein kinase B signaling cascade	GO:0051897	4	5.226e-04	1.357e-03
161	positive regulation of fat cell differentiation	GO:0045600	3	5.400e-04	1.391e-03
162	cellular response to UV	GO:0034644	3	5.400e-04	1.391e-03
163	response to glucocorticoid stimulus	GO:0051384	5	5.453e-04	1.398e-03
164	positive regulation of protein phosphorylation	GO:0001934	5	5.765e-04	1.457e-03
165	mitotic prometaphase	GO:0000236	5	6.090e-04	1.516e-03
166	nucleotide-excision repair, DNA damage removal	GO:0000718	3	6.262e-04	1.544e-03
167	protein import into nucleus, translocation	GO:0000060	3	6.262e-04	1.544e-03
168	cellular response to indole-3-methanol	GO:0071681	2	6.437e-04	1.577e-03
169	regulation of protein heterodimerization activity	GO:0043497	2	6.437e-04	1.577e-03
170	positive regulation of glucose metabolic process	GO:0010907	2	6.437e-04	1.577e-03
171	positive regulation of phosphoprotein phosphatase activity	GO:0032516	2	6.437e-04	1.577e-03
172	transformed cell apoptosis	GO:0006927	2	6.437e-04	1.577e-03
173	negative regulation of neural precursor cell proliferation	GO:2000178	2	6.437e-04	1.577e-03
174	negative regulation of osteoblast proliferation	GO:0033689	2	6.437e-04	1.577e-03
175	mitotic cell cycle arrest	GO:0071850	2	6.437e-04	1.577e-03
176	negative regulation of gene expression	GO:0010629	4	6.658e-04	1.616e-03
177	negative regulation of endothelial cell proliferation	GO:0001937	3	7.208e-04	1.712e-03
178	cellular response to drug	GO:0035690	3	7.208e-04	1.712e-03
179	protein tetramerization	GO:0051262	3	7.208e-04	1.712e-03
180	spleen development	GO:0048536	3	7.208e-04	1.712e-03
181	positive regulation of DNA repair	GO:0045739	3	7.208e-04	1.712e-03
182	DNA recombination	GO:0006310	5	7.927e-04	1.836e-03
183	pancreas development	GO:0031016	3	8.240e-04	1.888e-03
184	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	3	8.240e-04	1.888e-03
185	response to corticosterone stimulus	GO:0051412	3	8.240e-04	1.888e-03
186	G2/M transition DNA damage checkpoint	GO:0031572	3	8.240e-04	1.888e-03
187	response to testosterone stimulus	GO:0033574	3	8.240e-04	1.888e-03
188	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0043154	4	8.349e-04	1.908e-03
189	vasculogenesis	GO:0001570	4	8.974e-04	2.009e-03
190	peptidyl-threonine phosphorylation	GO:0018107	3	9.362e-04	2.074e-03
191	DNA damage checkpoint	GO:0000077	3	9.362e-04	2.074e-03
192	positive regulation of histone H3-K4 methylation	GO:0051571	2	9.605e-04	2.113e-03
193	activation-induced cell death of T cells	GO:0006924	2	9.605e-04	2.113e-03
194	signal transduction by p53 class mediator resulting in induction of apoptosis	GO:0072332	2	9.605e-04	2.113e-03
195	positive regulation of thymocyte apoptosis	GO:0070245	2	9.605e-04	2.113e-03
196	enucleate erythrocyte differentiation	GO:0043353	2	9.605e-04	2.113e-03
197	traversing start control point of mitotic cell cycle	GO:0007089	2	9.605e-04	2.113e-03
198	negative regulation of cell aging	GO:0090344	2	9.605e-04	2.113e-03
199	positive regulation of DNA biosynthetic process	GO:2000573	2	9.605e-04	2.113e-03
200	positive regulation of phospholipase C activity	GO:0010863	2	9.605e-04	2.113e-03
201	positive regulation of protein oligomerization	GO:0032461	2	9.605e-04	2.113e-03
202	positive regulation of histone deacetylation	GO:0031065	2	9.605e-04	2.113e-03
203	negative regulation of epithelial cell differentiation	GO:0030857	2	9.605e-04	2.113e-03
204	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:0043123	6	9.977e-04	2.174e-03
205	double-strand break repair	GO:0006302	4	1.032e-03	2.233e-03
206	negative regulation of phosphorylation	GO:0042326	3	1.058e-03	2.277e-03
207	response to progesterone stimulus	GO:0032570	3	1.058e-03	2.277e-03
208	regulation of cell proliferation	GO:0042127	5	1.064e-03	2.288e-03
209	regulation of transcription, DNA-dependent	GO:0006355	25	1.185e-03	2.469e-03
210	negative regulation of BMP signaling pathway	GO:0030514	3	1.188e-03	2.475e-03
211	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0043280	3	1.188e-03	2.475e-03
212	protein phosphorylation	GO:0006468	10	1.247e-03	2.572e-03
213	positive regulation of MAPK cascade	GO:0043410	4	1.260e-03	2.592e-03
214	blood coagulation	GO:0007596	11	1.275e-03	2.613e-03
215	protein autophosphorylation	GO:0046777	6	1.283e-03	2.624e-03
216	branching morphogenesis of a tube	GO:0048754	3	1.329e-03	2.694e-03
217	positive regulation of cyclin-dependent protein kinase activity involved in G1/S	GO:0031659	2	1.337e-03	2.705e-03
218	negative regulation of peptidyl-serine phosphorylation	GO:0033137	2	1.337e-03	2.705e-03
219	mitotic cell cycle G2/M transition DNA damage checkpoint	GO:0007095	2	1.337e-03	2.705e-03
220	DNA dealkylation involved in DNA repair	GO:0006307	2	1.337e-03	2.705e-03
221	regulation of neuron projection development	GO:0010975	2	1.337e-03	2.705e-03
222	embryonic morphogenesis	GO:0048598	2	1.337e-03	2.705e-03
223	regulation of reactive oxygen species metabolic process	GO:2000377	2	1.337e-03	2.705e-03
224	regulation of G1/S transition of mitotic cell cycle	GO:2000045	2	1.337e-03	2.705e-03
225	negative regulation of epithelial cell proliferation involved in prostate gland development	GO:0060770	2	1.337e-03	2.705e-03
226	cellular response to gamma radiation	GO:0071480	2	1.337e-03	2.705e-03
227	negative regulation of release of cytochrome c from mitochondria	GO:0090201	2	1.337e-03	2.705e-03
228	T cell differentiation in thymus	GO:0033077	3	1.480e-03	2.929e-03
229	response to peptide hormone stimulus	GO:0043434	4	1.521e-03	2.985e-03
230	glucose homeostasis	GO:0042593	4	1.521e-03	2.985e-03
231	cell migration	GO:0016477	5	1.527e-03	2.995e-03
232	response to oxidative stress	GO:0006979	5	1.593e-03	3.094e-03
233	TRIF-dependent toll-like receptor signaling pathway	GO:0035666	4	1.616e-03	3.125e-03
234	cell maturation	GO:0048469	3	1.641e-03	3.155e-03
235	negative regulation of osteoblast differentiation	GO:0045668	3	1.641e-03	3.155e-03
236	toll-like receptor 3 signaling pathway	GO:0034138	4	1.714e-03	3.269e-03
237	negative regulation of canonical Wnt receptor signaling pathway	GO:0090090	4	1.714e-03	3.269e-03
238	induction of apoptosis by extracellular signals	GO:0008624	5	1.733e-03	3.295e-03
239	induction of apoptosis by oxidative stress	GO:0008631	2	1.774e-03	3.347e-03
240	response to UV-B	GO:0010224	2	1.774e-03	3.347e-03
241	regulation of protein homodimerization activity	GO:0043496	2	1.774e-03	3.347e-03
242	positive regulation of catenin import into nucleus	GO:0035413	2	1.774e-03	3.347e-03
243	response to L-ascorbic acid	GO:0033591	2	1.774e-03	3.347e-03
244	positive regulation of protein homooligomerization	GO:0032464	2	1.774e-03	3.347e-03
245	T-helper 1 type immune response	GO:0042088	2	1.774e-03	3.347e-03
246	negative regulation of survival gene product expression	GO:0008634	2	1.774e-03	3.347e-03
247	transforming growth factor beta receptor signaling pathway	GO:0007179	4	1.817e-03	3.414e-03
248	MyD88-independent toll-like receptor signaling pathway	GO:0002756	4	1.924e-03	3.570e-03
249	multicellular organismal development	GO:0007275	17	1.968e-03	3.634e-03
250	hair follicle development	GO:0001942	3	1.994e-03	3.672e-03
251	thymus development	GO:0048538	3	1.994e-03	3.672e-03
252	protein import into nucleus	GO:0006606	3	1.994e-03	3.672e-03
253	response to glucose stimulus	GO:0009749	4	2.036e-03	3.724e-03
254	positive regulation of sequence-specific DNA binding transcription factor activity	GO:0051091	4	2.152e-03	3.890e-03
255	striated muscle cell differentiation	GO:0051146	2	2.268e-03	4.053e-03
256	axon regeneration	GO:0031103	2	2.268e-03	4.053e-03
257	signal transduction in response to DNA damage	GO:0042770	2	2.268e-03	4.053e-03
258	embryonic foregut morphogenesis	GO:0048617	2	2.268e-03	4.053e-03
259	response to magnesium ion	GO:0032026	2	2.268e-03	4.053e-03
260	response to folic acid	GO:0051593	2	2.268e-03	4.053e-03
261	ovulation from ovarian follicle	GO:0001542	2	2.268e-03	4.053e-03
262	positive regulation of protein export from nucleus	GO:0046827	2	2.268e-03	4.053e-03
263	growth	GO:0040007	3	2.392e-03	4.210e-03
264	cellular response to amino acid stimulus	GO:0071230	3	2.392e-03	4.210e-03
265	toll-like receptor 1 signaling pathway	GO:0034130	4	2.397e-03	4.214e-03
266	toll-like receptor 2 signaling pathway	GO:0034134	4	2.397e-03	4.214e-03
267	determination of adult lifespan	GO:0008340	2	2.821e-03	4.783e-03
268	response to reactive oxygen species	GO:0000302	2	2.821e-03	4.783e-03
269	negative regulation of chondrocyte differentiation	GO:0032331	2	2.821e-03	4.783e-03
270	negative regulation of blood vessel endothelial cell migration	GO:0043537	2	2.821e-03	4.783e-03
271	regulation of peptidyl-tyrosine phosphorylation	GO:0050730	2	2.821e-03	4.783e-03
272	ventricular cardiac muscle cell development	GO:0055015	2	2.821e-03	4.783e-03
273	cell migration involved in sprouting angiogenesis	GO:0002042	2	2.821e-03	4.783e-03
274	sexual reproduction	GO:0019953	2	2.821e-03	4.783e-03
275	oocyte development	GO:0048599	2	2.821e-03	4.783e-03
276	DNA synthesis involved in DNA repair	GO:0000731	2	2.821e-03	4.783e-03
277	response to vitamin E	GO:0033197	2	2.821e-03	4.783e-03
278	toll-like receptor signaling pathway	GO:0002224	4	2.943e-03	4.949e-03
279	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	4	2.943e-03	4.949e-03
280	cell-cell adhesion	GO:0016337	4	3.092e-03	5.154e-03
281	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051439	4	3.245e-03	5.356e-03
282	positive regulation of ERK1 and ERK2 cascade	GO:0070374	4	3.245e-03	5.356e-03
283	negative regulation of epithelial cell proliferation	GO:0050680	3	3.327e-03	5.463e-03
284	somitogenesis	GO:0001756	3	3.327e-03	5.463e-03
285	toll-like receptor 4 signaling pathway	GO:0034142	4	3.404e-03	5.549e-03
286	signal transduction	GO:0007165	19	3.423e-03	5.557e-03
287	maintenance of protein location in nucleus	GO:0051457	2	3.429e-03	5.562e-03
288	negative regulation of JUN kinase activity	GO:0043508	2	3.429e-03	5.562e-03
289	negative regulation of oligodendrocyte differentiation	GO:0048715	2	3.429e-03	5.562e-03
290	mitotic cell cycle G1/S transition checkpoint	GO:0031575	2	3.429e-03	5.562e-03
291	membrane protein intracellular domain proteolysis	GO:0031293	2	3.429e-03	5.562e-03
292	regulation of ERK1 and ERK2 cascade	GO:0070372	2	3.429e-03	5.562e-03
293	positive regulation of nitric-oxide synthase activity	GO:0051000	2	3.429e-03	5.562e-03
294	Toll signaling pathway	GO:0008063	4	3.569e-03	5.748e-03
295	positive regulation of phosphatidylinositol 3-kinase cascade	GO:0014068	3	3.591e-03	5.777e-03
296	multicellular organism growth	GO:0035264	3	3.867e-03	6.137e-03
297	osteoblast differentiation	GO:0001649	3	3.867e-03	6.137e-03
298	insulin-like growth factor receptor signaling pathway	GO:0048009	2	4.093e-03	6.423e-03
299	positive regulation of histone acetylation	GO:0035066	2	4.093e-03	6.423e-03
300	male meiosis I	GO:0007141	2	4.093e-03	6.423e-03
301	regulation of protein catabolic process	GO:0042176	2	4.093e-03	6.423e-03
302	prostanoid metabolic process	GO:0006692	2	4.093e-03	6.423e-03
303	positive regulation of release of cytochrome c from mitochondria	GO:0090200	2	4.093e-03	6.423e-03
304	negative regulation of MAPK cascade	GO:0043409	2	4.093e-03	6.423e-03
305	apoptotic mitochondrial changes	GO:0008637	2	4.093e-03	6.423e-03
306	mRNA stabilization	GO:0048255	2	4.093e-03	6.423e-03
307	branching involved in mammary gland duct morphogenesis	GO:0060444	2	4.093e-03	6.423e-03
308	centrosome duplication	GO:0051298	2	4.093e-03	6.423e-03
309	positive regulation of smooth muscle cell migration	GO:0014911	2	4.093e-03	6.423e-03
310	positive regulation of establishment of protein localization in plasma membrane	GO:0090004	2	4.093e-03	6.423e-03
311	response to hydrogen peroxide	GO:0042542	3	4.156e-03	6.496e-03
312	skeletal system development	GO:0001501	5	4.193e-03	6.548e-03
313	neuron differentiation	GO:0030182	4	4.279e-03	6.662e-03
314	regulation of gene expression	GO:0010468	3	4.458e-03	6.884e-03
315	activation of MAPK activity	GO:0000187	4	4.668e-03	7.145e-03
316	ovarian follicle development	GO:0001541	3	4.773e-03	7.253e-03
317	myoblast differentiation	GO:0045445	2	4.811e-03	7.305e-03
318	B cell homeostasis	GO:0001782	2	4.811e-03	7.305e-03
319	monocyte differentiation	GO:0030224	2	4.811e-03	7.305e-03
320	blood vessel morphogenesis	GO:0048514	2	4.811e-03	7.305e-03
321	positive regulation of microtubule polymerization	GO:0031116	2	4.811e-03	7.305e-03
322	T cell receptor signaling pathway	GO:0050852	4	4.871e-03	7.378e-03
323	cellular response to lipopolysaccharide	GO:0071222	3	5.100e-03	7.650e-03
324	positive regulation of canonical Wnt receptor signaling pathway	GO:0090263	3	5.100e-03	7.650e-03
325	response to retinoic acid	GO:0032526	3	5.441e-03	8.073e-03
326	positive regulation of cell division	GO:0051781	3	5.441e-03	8.073e-03
327	osteoclast differentiation	GO:0030316	2	5.584e-03	8.224e-03
328	temperature homeostasis	GO:0001659	2	5.584e-03	8.224e-03
329	regulation of smooth muscle contraction	GO:0006940	2	5.584e-03	8.224e-03
330	positive regulation of chondrocyte differentiation	GO:0032332	2	5.584e-03	8.224e-03
331	response to iron ion	GO:0010039	2	5.584e-03	8.224e-03
332	cellular response to vascular endothelial growth factor stimulus	GO:0035924	2	5.584e-03	8.224e-03
333	cell morphogenesis	GO:0000902	3	5.796e-03	8.490e-03
334	keratinocyte differentiation	GO:0030216	3	5.796e-03	8.490e-03
335	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	GO:0042787	3	6.163e-03	8.954e-03
336	regulation of catalytic activity	GO:0050790	3	6.163e-03	8.954e-03
337	nervous system development	GO:0007399	9	6.205e-03	9.001e-03
338	positive regulation of erythrocyte differentiation	GO:0045648	2	6.408e-03	9.227e-03
339	cellular response to glucocorticoid stimulus	GO:0071385	2	6.408e-03	9.227e-03
340	response to copper ion	GO:0046688	2	6.408e-03	9.227e-03
341	odontogenesis of dentin-containing tooth	GO:0042475	3	6.545e-03	9.386e-03
342	M phase of mitotic cell cycle	GO:0000087	4	6.711e-03	9.588e-03
343	negative regulation of angiogenesis	GO:0016525	3	6.940e-03	9.858e-03
344	regulation of lipid metabolic process	GO:0019216	2	7.285e-03	1.026e-02
345	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:0030949	2	7.285e-03	1.026e-02
346	regulation of interferon-gamma-mediated signaling pathway	GO:0060334	2	7.285e-03	1.026e-02
347	histone methylation	GO:0016571	2	7.285e-03	1.026e-02
348	telomere maintenance	GO:0000723	3	7.350e-03	1.033e-02
349	cellular component disassembly involved in apoptosis	GO:0006921	3	7.350e-03	1.033e-02
350	response to heat	GO:0009408	3	7.350e-03	1.033e-02
351	peptidyl-serine phosphorylation	GO:0018105	3	7.350e-03	1.033e-02
352	response to vitamin D	GO:0033280	2	8.213e-03	1.129e-02
353	DNA methylation	GO:0006306	2	8.213e-03	1.129e-02
354	nitric oxide metabolic process	GO:0046209	2	8.213e-03	1.129e-02
355	activation of NF-kappaB-inducing kinase activity	GO:0007250	2	8.213e-03	1.129e-02
356	positive regulation of transforming growth factor beta receptor signaling pathway	GO:0030511	2	8.213e-03	1.129e-02
357	SMAD protein signal transduction	GO:0060395	2	8.213e-03	1.129e-02
358	response to osmotic stress	GO:0006970	2	8.213e-03	1.129e-02
359	negative regulation of I-kappaB kinase/NF-kappaB cascade	GO:0043124	2	8.213e-03	1.129e-02
360	MAPK cascade	GO:0000165	3	9.127e-03	1.236e-02
361	cellular response to heat	GO:0034605	2	9.190e-03	1.244e-02
362	positive regulation of DNA binding	GO:0043388	2	9.190e-03	1.244e-02
363	endothelial cell migration	GO:0043542	2	9.190e-03	1.244e-02
364	myeloid cell differentiation	GO:0030099	2	9.190e-03	1.244e-02
365	nucleobase-containing small molecule interconversion	GO:0015949	2	9.190e-03	1.244e-02
366	cell chemotaxis	GO:0060326	2	1.022e-02	1.360e-02
367	regulation of long-term neuronal synaptic plasticity	GO:0048169	2	1.022e-02	1.360e-02
368	oligodendrocyte development	GO:0014003	2	1.022e-02	1.360e-02
369	positive regulation of cell death	GO:0010942	2	1.022e-02	1.360e-02
370	regulation of protein stability	GO:0031647	2	1.022e-02	1.360e-02
371	response to hyperoxia	GO:0055093	2	1.022e-02	1.360e-02
372	response to cadmium ion	GO:0046686	2	1.022e-02	1.360e-02
373	protein dephosphorylation	GO:0006470	4	1.025e-02	1.363e-02
374	cell surface receptor signaling pathway	GO:0007166	5	1.122e-02	1.473e-02
375	hindbrain development	GO:0030902	2	1.129e-02	1.482e-02
376	digestive tract development	GO:0048565	2	1.129e-02	1.482e-02
377	reactive oxygen species metabolic process	GO:0072593	2	1.129e-02	1.482e-02
378	platelet-derived growth factor receptor signaling pathway	GO:0048008	2	1.129e-02	1.482e-02
379	gastrulation	GO:0007369	2	1.129e-02	1.482e-02
380	aging	GO:0007568	4	1.129e-02	1.482e-02
381	positive regulation of cell growth	GO:0030307	3	1.167e-02	1.525e-02
382	central nervous system development	GO:0007417	4	1.202e-02	1.562e-02
383	axon guidance	GO:0007411	7	1.241e-02	1.606e-02
384	collagen catabolic process	GO:0030574	2	1.242e-02	1.606e-02
385	positive regulation of vasoconstriction	GO:0045907	2	1.242e-02	1.606e-02
386	positive chemotaxis	GO:0050918	2	1.242e-02	1.606e-02
387	response to bacterium	GO:0009617	2	1.242e-02	1.606e-02
388	brain development	GO:0007420	5	1.264e-02	1.632e-02
389	response to insulin stimulus	GO:0032868	3	1.280e-02	1.649e-02
390	chromosome segregation	GO:0007059	3	1.280e-02	1.649e-02
391	neuron projection development	GO:0031175	3	1.338e-02	1.714e-02
392	negative regulation of tumor necrosis factor production	GO:0032720	2	1.358e-02	1.737e-02
393	proximal/distal pattern formation	GO:0009954	2	1.358e-02	1.737e-02
394	release of sequestered calcium ion into cytosol	GO:0051209	2	1.358e-02	1.737e-02
395	cellular response to starvation	GO:0009267	2	1.358e-02	1.737e-02
396	nucleobase-containing compound metabolic process	GO:0006139	3	1.398e-02	1.781e-02
397	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	3	1.459e-02	1.847e-02
398	cellular response to hydrogen peroxide	GO:0070301	2	1.480e-02	1.867e-02
399	inactivation of MAPK activity	GO:0000188	2	1.480e-02	1.867e-02
400	positive regulation of protein catabolic process	GO:0045732	2	1.480e-02	1.867e-02
401	DNA metabolic process	GO:0006259	2	1.480e-02	1.867e-02
402	cellular response to oxidative stress	GO:0034599	2	1.480e-02	1.867e-02
403	positive regulation of phosphorylation	GO:0042327	2	1.606e-02	2.007e-02
404	JAK-STAT cascade involved in growth hormone signaling pathway	GO:0060397	2	1.606e-02	2.007e-02
405	DNA fragmentation involved in apoptotic nuclear change	GO:0006309	2	1.606e-02	2.007e-02
406	positive regulation of multicellular organism growth	GO:0040018	2	1.606e-02	2.007e-02
407	embryonic placenta development	GO:0001892	2	1.606e-02	2.007e-02
408	vascular endothelial growth factor receptor signaling pathway	GO:0048010	2	1.736e-02	2.147e-02
409	negative regulation of DNA binding	GO:0043392	2	1.736e-02	2.147e-02
410	face morphogenesis	GO:0060325	2	1.736e-02	2.147e-02
411	mesoderm formation	GO:0001707	2	1.736e-02	2.147e-02
412	positive regulation of endothelial cell migration	GO:0010595	2	1.736e-02	2.147e-02
413	inflammatory response	GO:0006954	6	1.736e-02	2.147e-02
414	negative regulation of cell death	GO:0060548	2	1.871e-02	2.291e-02
415	positive regulation of protein binding	GO:0032092	2	1.871e-02	2.291e-02
416	nucleobase-containing small molecule metabolic process	GO:0055086	3	1.931e-02	2.354e-02
417	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:0051437	3	2.004e-02	2.431e-02
418	JAK-STAT cascade	GO:0007259	2	2.010e-02	2.438e-02
419	regulation of type I interferon-mediated signaling pathway	GO:0060338	2	2.010e-02	2.438e-02
420	response to starvation	GO:0042594	2	2.010e-02	2.438e-02
421	protein autoubiquitination	GO:0051865	2	2.010e-02	2.438e-02
422	response to amino acid stimulus	GO:0043200	2	2.010e-02	2.438e-02
423	neural tube development	GO:0021915	2	2.154e-02	2.592e-02
424	learning or memory	GO:0007611	2	2.154e-02	2.592e-02
425	response to axon injury	GO:0048678	2	2.154e-02	2.592e-02
426	patterning of blood vessels	GO:0001569	2	2.301e-02	2.746e-02
427	cell fate commitment	GO:0045165	2	2.301e-02	2.746e-02
428	odontogenesis	GO:0042476	2	2.452e-02	2.911e-02
429	metanephros development	GO:0001656	2	2.452e-02	2.911e-02
430	neuron development	GO:0048666	2	2.452e-02	2.911e-02
431	response to activity	GO:0014823	2	2.452e-02	2.911e-02
432	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO:0032436	2	2.452e-02	2.911e-02
433	DNA strand elongation involved in DNA replication	GO:0006271	2	2.608e-02	3.077e-02
434	tissue development	GO:0009888	2	2.767e-02	3.244e-02
435	cellular response to hormone stimulus	GO:0032870	2	2.767e-02	3.244e-02
436	response to nutrient levels	GO:0031667	2	2.767e-02	3.244e-02
437	leukotriene biosynthetic process	GO:0019370	2	2.767e-02	3.244e-02
438	smoothened signaling pathway	GO:0007224	2	2.767e-02	3.244e-02
439	immune response	GO:0006955	7	2.930e-02	3.417e-02
440	cell differentiation	GO:0030154	9	2.952e-02	3.441e-02
441	positive regulation of B cell proliferation	GO:0030890	2	3.097e-02	3.590e-02
442	positive regulation of translation	GO:0045727	2	3.097e-02	3.590e-02
443	carbohydrate transport	GO:0008643	2	3.097e-02	3.590e-02
444	protein homooligomerization	GO:0051260	3	3.097e-02	3.591e-02
445	pattern specification process	GO:0007389	3	3.192e-02	3.692e-02
446	positive regulation of protein ubiquitination	GO:0031398	2	3.442e-02	3.946e-02
447	cytokine-mediated signaling pathway	GO:0019221	5	3.554e-02	4.065e-02
448	humoral immune response	GO:0006959	2	3.619e-02	4.133e-02
449	embryonic limb morphogenesis	GO:0030326	2	3.619e-02	4.133e-02
450	fat cell differentiation	GO:0045444	2	3.619e-02	4.133e-02
451	ureteric bud development	GO:0001657	2	3.619e-02	4.133e-02
452	acute-phase response	GO:0006953	2	3.619e-02	4.133e-02
453	embryonic digit morphogenesis	GO:0042733	2	3.800e-02	4.318e-02
454	I-kappaB kinase/NF-kappaB cascade	GO:0007249	2	3.800e-02	4.318e-02
455	regulation of transcription from RNA polymerase II promoter	GO:0006357	5	3.912e-02	4.436e-02
456	endocrine pancreas development	GO:0031018	2	3.985e-02	4.509e-02
457	protein heterooligomerization	GO:0051291	2	3.985e-02	4.509e-02
458	angiogenesis	GO:0001525	4	3.997e-02	4.521e-02
459	protein ubiquitination	GO:0016567	4	4.075e-02	4.602e-02
460	anatomical structure morphogenesis	GO:0009653	3	4.222e-02	4.756e-02
461	positive regulation of NF-kappaB transcription factor activity	GO:0051092	3	4.222e-02	4.756e-02
462	negative regulation of inflammatory response	GO:0050728	2	4.364e-02	4.900e-02